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Gene Review

pilU  -  twitching motility protein PilU

Pseudomonas aeruginosa PAO1

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Disease relevance of pilU

  • A broader survey showed differential patterns of sensitivity to various fimbrial-specific phages among the pilU mutants and other twitching-motility mutants in the transposon library [1].
  • An open reading frame downstream of the pilT locus encoding a 408-amino-acid protein with 33% identity with the gonococcal PilT protein and 45% identity with the PilU protein in Pseudomonas aeruginosa was characterized, and the corresponding gene was designated pilU [2].

High impact information on pilU

  • However, in contrast to pilT mutants, the pilU mutants had not also acquired resistance to infection by bacteriophage PO4 [1].
  • Like pilT mutants, the pilU mutants were hyperfimbriate, but in neither case was this associated with an increase in transcription of the fimbrial subunit gene pilA [1].
  • However, loss-of-function mutations in pilU increased bacterial adherence to ME-180 human epithelial cells eightfold and disrupted in vitro Tfp-associated autoagglutination [2].


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