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Gene Review

pilO  -  type 4 fimbrial biogenesis protein PilO

Pseudomonas aeruginosa PAO1

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Disease relevance of pilO


High impact information on pilO

  • A role for pilO in the glycosylation of pilin in P. aeruginosa is evident as the cloned pilAO operon produced glycosylated strain 1244 pilin in eight heterologous P. aeruginosa strains [2].
  • A 2200 base mRNA strand, which contained both the pilO and pilA transcripts, was produced from this region, while a 650 base transcript containing only pilA was present in a 100-fold excess over the longer transcript [1].


  1. pilO, a gene required for glycosylation of Pseudomonas aeruginosa 1244 pilin. Castric, P. Microbiology (Reading, Engl.) (1995) [Pubmed]
  2. Glycosylation of Pseudomonas aeruginosa 1244 pilin: glycan substrate specificity. DiGiandomenico, A., Matewish, M.J., Bisaillon, A., Stehle, J.R., Lam, J.S., Castric, P. Mol. Microbiol. (2002) [Pubmed]
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