Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ndh - NADH dehydrogenase

Mycobacterium tuberculosis H37Rv

Guo, H. et al., Lee, A.S. et al., Lee, A.S. et al.

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Disease relevance of ndh

Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates [1].

High impact information on ndh

Seven isoniazid-resistant isolates with mutations in the NADH dehydrogenase (ndh) gene were molecularly typed by IS6110-based restriction fragment length polymorphism analysis [2].
Three of 33 strains (9 %) had no mutations in katG, inhA or ndh, indicating that their resistance was due to a new mechanism of resistance [3].

Associations of ndh with chemical compounds

Mutations in ndh appear to be an additional molecular mechanism for isoniazid resistance in M. tuberculosis [1].

References

Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates. Lee, A.S., Teo, A.S., Wong, S.Y. Antimicrob. Agents Chemother. (2001) [Pubmed]
Discrimination of single-copy IS6110 DNA fingerprints of Mycobacterium tuberculosis isolates by high-resolution minisatellite-based typing. Lee, A.S., Tang, L.L., Lim, I.H., Bellamy, R., Wong, S.Y. J. Clin. Microbiol. (2002) [Pubmed]
Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA. Guo, H., Seet, Q., Denkin, S., Parsons, L., Zhang, Y. J. Med. Microbiol. (2006) [Pubmed]

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