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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TAX1BP1  -  Tax1 (human T-cell leukemia virus type I)...

Homo sapiens

Synonyms: CALCOCO3, PRO0105, T6BP, TRAF6-binding protein, TXBP151, ...
 
 
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Disease relevance of TAX1BP1

  • A cDNA fragment was isolated which encoded a portion of a novel protein (TXBP151), which was recently found to be a human T-cell leukemia virus type-I (HTLV-I) Tax-binding protein [1].
 

High impact information on TAX1BP1

  • IL-1, but not tumor necrosis factor, induces TRAF6-T6BP complex formation in a ligand-dependent manner [2].
  • Like A20, overexpression of TXBP151 could inhibit apoptosis induced by tumour necrosis factor (TNF) in NIH3T3 cells [1].
  • Moreover, transfection of antisense TXBP151 partially abolished the anti-apoptotic effect of A20 [1].
  • Here we discuss findings describing the role of MAD1 in exit of cells from mitosis and TXBP151 in NF-kappaB activation [3].
  • Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein [4].
 

Biological context of TAX1BP1

References

  1. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. De Valck, D., Jin, D.Y., Heyninck, K., Van de Craen, M., Contreras, R., Fiers, W., Jeang, K.T., Beyaert, R. Oncogene (1999) [Pubmed]
  2. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Ling, L., Goeddel, D.V. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-kappaB activation. Iha, H., Kasai, T., Kibler, K.V., Iwanaga, Y., Tsurugi, K., Jeang, K.T. AIDS Res. Hum. Retroviruses (2000) [Pubmed]
  4. Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein. Mireskandari, A., Reid, R.L., Kashanchi, F., Dittmer, J., Li, W.B., Brady, J.N. Biochim. Biophys. Acta (1996) [Pubmed]
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