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Gene Review:

gltX - glutamyl-tRNA synthetase

Helicobacter pylori J99

Salazar, J.C. et al.

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Disease relevance of gltX

To determine the tRNA preferences of GluRS, we chose the duplicated enzyme sets from Helicobacter pylori and Acidithiobacillus ferrooxidans [1].

High impact information on gltX

The coexistence of the two GluRS enzymes in one organism may lay the groundwork for the acquisition of the canonical glutaminyl-tRNA synthetase by lateral gene transfer from eukaryotes [1].
Although most organisms encode only one GluRS, a number of bacteria encode two different GluRS proteins; yet, the tRNA specificity of these enzymes and the reason for such gene duplications are unknown [1].

References

Coevolution of an aminoacyl-tRNA synthetase with its tRNA substrates. Salazar, J.C., Ahel, I., Orellana, O., Tumbula-Hansen, D., Krieger, R., Daniels, L., Söll, D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]

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