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Gene Review:

EIF2B3 - eukaryotic translation initiation factor...

Homo sapiens

Synonyms: EIF-2B, EIF2Bgamma, Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma

Price, N.T. et al., Kruger, M. et al., Welsh, G.I. et al.

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Disease relevance of EIF2B3

Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach [1].

High impact information on EIF2B3

The rapid activation of EIF2B following mitogenic stimulation of T-cells is therefore mediated by factors other than its own concentration [2].
This was used to screen a rat skeletal muscle cDNA library, and a clone encoding rat eIF2B gamma was isolated [3].
Searching the database of expressed sequence tags (dbEST) revealed nucleotide sequences potentially encoding human eIF2B gamma that contained peptides corresponding to those from the rabbit subunit [3].

References

Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. Kruger, M., Beger, C., Li, Q.X., Welch, P.J., Tritz, R., Leavitt, M., Barber, J.R., Wong-Staal, F. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. Welsh, G.I., Miyamoto, S., Price, N.T., Safer, B., Proud, C.G. J. Biol. Chem. (1996) [Pubmed]
Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Price, N.T., Kimball, S.R., Jefferson, L.S., Proud, C.G. Biochem. J. (1996) [Pubmed]

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AT5G19485	Arabidopsis thaliana
EIF2B3	Bos taurus
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MGG_02390	Magnaporthe oryzae 70-15
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NCU03548	Neurospora crassa OR74A
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tif223	Schizosaccharomyces pombe 972h-
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