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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Hepatitis C

 
 
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Disease relevance of Hepatitis C

 

Psychiatry related information on Hepatitis C

 

High impact information on Hepatitis C

  • RESULTS: At the completion of treatment, serum levels of hepatitis C virus (HCV) RNA were undetectable in 141 of the 173 patients who were treated with interferon and ribavirin and in 80 of the 172 patients who were treated with interferon alone (82 percent vs. 47 percent, P<0.001) [11].
  • During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3 [12].
  • We used three markers to detect hepatitis C virus (HCV) infection in stored samples of serum: antibody to HCV (anti-HCV) detected by second-generation serologic assays; HCV RNA detected by polymerase-chain-reaction assay; and antibody to HCV antigen (anti-HCVAg) detected by fluorescent-antibody-blocking assay [13].
  • Here we show that the tetraspanin CD81, a putative receptor for hepatitis C virus, is required on hepatocytes for human Plasmodium falciparum and rodent Plasmodium yoelii sporozoite infectivity [14].
  • Hepatitis C virus, the E2 envelope protein, and alpha-interferon resistance [15].
 

Chemical compound and disease context of Hepatitis C

 

Biological context of Hepatitis C

 

Anatomical context of Hepatitis C

  • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions [26].
  • Analysis of the peripheral blood T cell proliferative response to core, E1, E2, NS3, NS4, and NS5 recombinant antigens and synthetic peptides showed that responses to all hepatitis C virus antigens, except E1, were significantly more vigorous and more frequently detectable in patients who normalized transaminase levels than in those who did not [27].
  • Suppression or overexpression of La protein and polypyrimidine tract binding protein in RCF-26 significantly changed hepatitis C virus internal ribosome entry site activity [28].
  • The CD11c-enriched dendritic cell population obtained from the spleen was transduced in vitro with recombinant hepatitis C virus core and nonstructural 5 proteins by using macromolecular-based protein delivery [29].
  • We reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) proteins activate inflammatory pathways in monocytes [30].
 

Gene context of Hepatitis C

 

Analytical, diagnostic and therapeutic context of Hepatitis C

References

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  14. Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Silvie, O., Rubinstein, E., Franetich, J.F., Prenant, M., Belnoue, E., Rénia, L., Hannoun, L., Eling, W., Levy, S., Boucheix, C., Mazier, D. Nat. Med. (2003) [Pubmed]
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  24. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Okuda, M., Li, K., Beard, M.R., Showalter, L.A., Scholle, F., Lemon, S.M., Weinman, S.A. Gastroenterology (2002) [Pubmed]
  25. Viral error catastrophe by mutagenic nucleosides. Anderson, J.P., Daifuku, R., Loeb, L.A. Annu. Rev. Microbiol. (2004) [Pubmed]
  26. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. Tseng, C.T., Klimpel, G.R. J. Exp. Med. (2002) [Pubmed]
  27. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. Missale, G., Bertoni, R., Lamonaca, V., Valli, A., Massari, M., Mori, C., Rumi, M.G., Houghton, M., Fiaccadori, F., Ferrari, C. J. Clin. Invest. (1996) [Pubmed]
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  29. Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens. Kuzushita, N., Gregory, S.H., Monti, N.A., Carlson, R., Gehring, S., Wands, J.R. Gastroenterology (2006) [Pubmed]
  30. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Dolganiuc, A., Oak, S., Kodys, K., Golenbock, D.T., Finberg, R.W., Kurt-Jones, E., Szabo, G. Gastroenterology (2004) [Pubmed]
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  32. Translational repression by a novel partner of human poly(A) binding protein, Paip2. Khaleghpour, K., Svitkin, Y.V., Craig, A.W., DeMaria, C.T., Deo, R.C., Burley, S.K., Sonenberg, N. Mol. Cell (2001) [Pubmed]
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