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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNORD73A  -  small nucleolar RNA, C/D box 73A

Homo sapiens

Synonyms: RNU73, RNU73A, U73, U73a
 
 
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Disease relevance of SNORD73A

  • The cysteine-tRNA synthetase of Escherichia coli has domains that select for tRNAs containing U73, the GCA anticodon, and a specific tertiary structure at the corner of the tRNA L shape [1].
 

High impact information on SNORD73A

  • We show here that, although the Escherichia coli and human cysteinyl-tRNA synthetases both recognize the same bases (U73 and the GCA anticodon) of tRNA for aminoacylation, they have different emphasis on the tRNA backbone [2].
  • We propose that U73 is involved in methylation of the G1739 residue of the human 28S rRNA [3].
  • In addition, we present the mapping of human ribosomal protein S3a gene (hRPS3a) and internally nested U73 gene to the human chromosome 4q31.2-3 [3].
  • A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes [3].

References

  1. Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase. Lipman, R.S., Hou, Y.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Recognition of tRNA backbone for aminoacylation with cysteine: evolution from Escherichia coli to human. Ming, X., Smith, K., Suga, H., Hou, Y.M. J. Mol. Biol. (2002) [Pubmed]
  3. A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes. Rebane, A., Tamme, R., Laan, M., Pata, I., Metspalu, A. Gene (1998) [Pubmed]
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