The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

UNC5A  -  unc-5 homolog A (C. elegans)

Homo sapiens

Synonyms: KIAA1976, Netrin receptor UNC5A, Protein unc-5 homolog 1, Protein unc-5 homolog A, UNC5H1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on UNC5A

  • UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1 [1].
  • The lossreduction of expression may be a crucial mechanism for tumorigenicity because the expression of UNC5H1, UNC5H2, or UNC5H3 inhibits tumor cell anchorage-independent growth and invasion [2].
  • We mapped the NRAGE binding domain of UNC5H1 to its ZU-5 domain and show that this region, in addition to an adjacent PEST sequence, is required for UNC5H1-mediated apoptosis [3].

References

  1. UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Williams, M.E., Lu, X., McKenna, W.L., Washington, R., Boyette, A., Strickland, P., Dillon, A., Kaprielian, Z., Tessier-Lavigne, M., Hinck, L. Nat. Neurosci. (2006) [Pubmed]
  2. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Thiebault, K., Mazelin, L., Pays, L., Llambi, F., Joly, M.O., Scoazec, J.Y., Saurin, J.C., Romeo, G., Mehlen, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE. Williams, M.E., Strickland, P., Watanabe, K., Hinck, L. J. Biol. Chem. (2003) [Pubmed]
 
WikiGenes - Universities