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Gene Review

UNC5A  -  unc-5 homolog A (C. elegans)

Homo sapiens

Synonyms: KIAA1976, Netrin receptor UNC5A, Protein unc-5 homolog 1, Protein unc-5 homolog A, UNC5H1
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High impact information on UNC5A

  • UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1 [1].
  • The lossreduction of expression may be a crucial mechanism for tumorigenicity because the expression of UNC5H1, UNC5H2, or UNC5H3 inhibits tumor cell anchorage-independent growth and invasion [2].
  • We mapped the NRAGE binding domain of UNC5H1 to its ZU-5 domain and show that this region, in addition to an adjacent PEST sequence, is required for UNC5H1-mediated apoptosis [3].


  1. UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Williams, M.E., Lu, X., McKenna, W.L., Washington, R., Boyette, A., Strickland, P., Dillon, A., Kaprielian, Z., Tessier-Lavigne, M., Hinck, L. Nat. Neurosci. (2006) [Pubmed]
  2. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Thiebault, K., Mazelin, L., Pays, L., Llambi, F., Joly, M.O., Scoazec, J.Y., Saurin, J.C., Romeo, G., Mehlen, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE. Williams, M.E., Strickland, P., Watanabe, K., Hinck, L. J. Biol. Chem. (2003) [Pubmed]
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