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Gene Review:

UNC5C - unc-5 homolog C (C. elegans)

Homo sapiens

Synonyms: Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C, UNC5H3

Thiebault, K. et al., Ackerman, S.L. et al., Klar, J. et al.

Ackerman, Knowles,

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Disease relevance of UNC5C

Moreover, sequencing of UNC5C gene in patients with colorectal tumors revealed the presence of missense mutations [1].
We show here that the expression of the human UNC5A, UNC5B, or UNC5C is down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers [1].
By radiation hybrid analysis, we have determined that UNC5C localizes to chromosome 4q21-q23 between markers D4S1557 and D4S836 and is closely linked to the Parkinson disease gene [2].

High impact information on UNC5C

The rearrangement creates a fusion gene, which includes the RORa1 exon 1 and UNC5C that is expressed in frame in adipocytes from the affected patients [3].
Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23 [2].

References

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Thiebault, K., Mazelin, L., Pays, L., Llambi, F., Joly, M.O., Scoazec, J.Y., Saurin, J.C., Romeo, G., Mehlen, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. Ackerman, S.L., Knowles, B.B. Genomics (1998) [Pubmed]
RAR-related orphan receptor A isoform 1 (RORa1) is disrupted by a balanced translocation t(4;15)(q22.3;q21.3) associated with severe obesity. Klar, J., Asling, B., Carlsson, B., Ulvsbäck, M., Dellsén, A., Ström, C., Rhedin, M., Forslund, A., Annerén, G., Ludvigsson, J.F., Dahl, N. Eur. J. Hum. Genet. (2005) [Pubmed]

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AgaP_AGAP009061	Anopheles gambiae str. PEST
UNC5C	Bos taurus
UNC5C	Canis lupus familiaris
unc5c	Danio rerio
unc-5	Drosophila melanogaster
UNC5C	Gallus gallus
UNC5C	Macaca mulatta
Unc5c	Mus musculus
UNC5C	Pan troglodytes
Unc5c	Rattus norvegicus
unc5c	Xenopus (Silurana) tropicalis

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