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Gene Review

UNC5C  -  unc-5 homolog C (C. elegans)

Homo sapiens

Synonyms: Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C, UNC5H3
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Disease relevance of UNC5C


High impact information on UNC5C


  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Thiebault, K., Mazelin, L., Pays, L., Llambi, F., Joly, M.O., Scoazec, J.Y., Saurin, J.C., Romeo, G., Mehlen, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. Ackerman, S.L., Knowles, B.B. Genomics (1998) [Pubmed]
  3. RAR-related orphan receptor A isoform 1 (RORa1) is disrupted by a balanced translocation t(4;15)(q22.3;q21.3) associated with severe obesity. Klar, J., Asling, B., Carlsson, B., Ulvsbäck, M., Dellsén, A., Ström, C., Rhedin, M., Forslund, A., Annerén, G., Ludvigsson, J.F., Dahl, N. Eur. J. Hum. Genet. (2005) [Pubmed]
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