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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UBE2M  -  ubiquitin-conjugating enzyme E2M

Homo sapiens

Synonyms: NEDD8 carrier protein, NEDD8 protein ligase, NEDD8-conjugating enzyme Ubc12, UBC-RS2, UBC12, ...
 
 
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High impact information on UBE2M

  • The structure and associated mutational analyses reveal molecular details of Ubc12 recruitment by NEDD8's E1 [1].
  • We show that expression of APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and that this function requires both hUba3 and hUbc12 [2].
  • To characterize this family of E3 ligases in intact cells, we generated a cell line with tetracycline-inducible expression of a dominant-negative mutant of the Nedd8-conjugating enzyme Ubc12, a reported inhibitor of cullin neddylation [3].
  • Using this cell line, we demonstrate that the substrate recognition subunit Skp2 and the adaptor protein Skp1 are subject to Ubc12-dependent autoubiquitination and degradation [3].
  • In vitro systems for NEDD8 conjugation by Ubc12 [4].
 

Other interactions of UBE2M

  • One of the identified targets of copine I is the NEDD8-conjugating enzyme UBC12 (ubiquitin C12), that promotes the degradation of IkappaB through the ubiquitin ligase enzyme complex SCF(betaTrCP) [5].
  • Therefore the copine dominant-negative construct might inhibit TNF-alpha signalling by dysregulation or mislocalization of UBC12 [5].

References

  1. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Huang, D.T., Paydar, A., Zhuang, M., Waddell, M.B., Holton, J.M., Schulman, B.A. Mol. Cell (2005) [Pubmed]
  2. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. Chen, Y., McPhie, D.L., Hirschberg, J., Neve, R.L. J. Biol. Chem. (2000) [Pubmed]
  3. Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells - Evidence for cullin dimerization. Chew, E.H., Poobalasingam, T., Hawkey, C.J., Hagen, T. Cell. Signal. (2007) [Pubmed]
  4. In vitro systems for NEDD8 conjugation by Ubc12. Chiba, T. Meth. Enzymol. (2005) [Pubmed]
  5. Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine. Tomsig, J.L., Sohma, H., Creutz, C.E. Biochem. J. (2004) [Pubmed]
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