Gene Review:
NAE1 - NEDD8 activating enzyme E1 subunit 1
Homo sapiens
Synonyms:
A-116A10.1, APP-BP1, APPBP1, Amyloid beta precursor protein-binding protein 1, 59 kDa, Amyloid protein-binding protein 1, ...
- APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin. Chen, Y.Z. Apoptosis (2004)
- Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Fackler, O.T., Luo, W., Geyer, M., Alberts, A.S., Peterlin, B.M. Mol. Cell (1999)
- Burkitt lymphoma in the mouse. Kovalchuk, A.L., Qi, C.F., Torrey, T.A., Taddesse-Heath, L., Feigenbaum, L., Park, S.S., Gerbitz, A., Klobeck, G., Hoertnagel, K., Polack, A., Bornkamm, G.W., Janz, S., Morse, H.C. J. Exp. Med. (2000)
- Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. Zappulla, J.P., Dubreuil, P., Desbois, S., Létard, S., Hamouda, N.B., Daëron, M., Delsol, G., Arock, M., Liblau, R.S. J. Exp. Med. (2005)
- Oncogene expression in autoimmune and normal peripheral blood mononuclear cells. Klinman, D.M., Mushinski, J.F., Honda, M., Ishigatsubo, Y., Mountz, J.D., Raveche, E.S., Steinberg, A.D. J. Exp. Med. (1986)
- APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. Chen, Y., Liu, W., McPhie, D.L., Hassinger, L., Neve, R.L. J. Cell Biol. (2003)
- Expression of c-Fos-like immunoreactivity in the brain of mice with learned helplessness. Huang, Y.H., Cheng, C.Y., Hong, C.J., Tsai, S.J. Neurosci. Lett. (2004)
- Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Broccoli, D., Smogorzewska, A., Chong, L., de Lange, T. Nat. Genet. (1997)
- An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. Krontiris, T.G., Devlin, B., Karp, D.D., Robert, N.J., Risch, N. N. Engl. J. Med. (1993)
- Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. Martinet, Y., Rom, W.N., Grotendorst, G.R., Martin, G.R., Crystal, R.G. N. Engl. J. Med. (1987)
- Interaction between the retinoblastoma protein and the oncoprotein MDM2. Xiao, Z.X., Chen, J., Levine, A.J., Modjtahedi, N., Xing, J., Sellers, W.R., Livingston, D.M. Nature (1995)
- A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Chan, L.C., Karhi, K.K., Rayter, S.I., Heisterkamp, N., Eridani, S., Powles, R., Lawler, S.D., Groffen, J., Foulkes, J.G., Greaves, M.F. Nature (1987)
- Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Vähäkangas, K.H., Samet, J.M., Metcalf, R.A., Welsh, J.A., Bennett, W.P., Lane, D.P., Harris, C.C. Lancet (1992)
- Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene. He, J., deCastro, C.M., Vandenbark, G.R., Busciglio, J., Gabuzda, D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Hurwitz, E., Stancovski, I., Sela, M., Yarden, Y. Proc. Natl. Acad. Sci. U.S.A. (1995)
- TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines. Soman, N.R., Wogan, G.N., Rhim, J.S. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Effects of steroid hormones and peptide growth factors on protooncogene c-fos expression in human breast cancer cells. Wilding, G., Lippman, M.E., Gelmann, E.P. Cancer Res. (1988)
- The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. Chen, Y., McPhie, D.L., Hirschberg, J., Neve, R.L. J. Biol. Chem. (2000)
- Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Merlino, G.T., Xu, Y.H., Ishii, S., Clark, A.J., Semba, K., Toyoshima, K., Yamamoto, T., Pastan, I. Science (1984)
- Mouse tumor model for neurofibromatosis type 1. Vogel, K.S., Klesse, L.J., Velasco-Miguel, S., Meyers, K., Rushing, E.J., Parada, L.F. Science (1999)
- The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. Cory, G.O., Lovering, R.C., Hinshelwood, S., MacCarthy-Morrogh, L., Levinsky, R.J., Kinnon, C. J. Exp. Med. (1995)
- Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. Wossning, T., Herzog, S., K??hler, F., Meixlsperger, S., Kulathu, Y., Mittler, G., Abe, A., Fuchs, U., Borkhardt, A., Jumaa, H. J. Exp. Med. (2006)
- Inhibition of c-fes expression by an antisense oligomer causes apoptosis of HL60 cells induced to granulocytic differentiation. Manfredini, R., Grande, A., Tagliafico, E., Barbieri, D., Zucchini, P., Citro, G., Zupi, G., Franceschi, C., Torelli, U., Ferrari, S. J. Exp. Med. (1993)
- Expression of c-fos protooncogene in normal human peripheral blood granulocytes. Colotta, F., Wang, J.M., Polentarutti, N., Mantovani, A. J. Exp. Med. (1987)
- Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S.A., Petit, P.X., Mignotte, B., Kroemer, G. J. Exp. Med. (1995)
- Avian osteoclasts as estrogen target cells. Oursler, M.J., Osdoby, P., Pyfferoen, J., Riggs, B.L., Spelsberg, T.C. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav. Zheng, L., Sjölander, A., Eckerdal, J., Andersson, T. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Myb protein binds to human immunodeficiency virus 1 long terminal repeat (LTR) sequences and transactivates LTR-mediated transcription. Dasgupta, P., Saikumar, P., Reddy, C.D., Reddy, E.P. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression. Foulkes, N.S., Laoide, B.M., Schlotter, F., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Internalization of glial cell-derived neurotrophic factor receptor GFR alpha 1 in the absence of the ret tyrosine kinase coreceptor. Vieira, P., Thomas-Crusells, J., Vieira, A. Cell. Mol. Neurobiol. (2003)
- p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl. Salgia, R., Sattler, M., Pisick, E., Li, J.L., Griffin, J.D. Exp. Hematol. (1996)
- ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). Feo, S., Arcuri, D., Piddini, E., Passantino, R., Giallongo, A. FEBS Lett. (2000)
- Tyrosine phosphorylation and activation of pp60c-src and pp125FAK in bradykinin-stimulated fibroblasts. Lee, K.M., Villereal, M.L. Am. J. Physiol. (1996)
- Codons 12 and 13 of H-ras protooncogene interrupt the progression of DNA synthesis catalyzed by DNA polymerase alpha. Hoffmann, J.S., Fry, M., Ji, J., Williams, K.J., Loeb, L.A. Cancer Res. (1993)
- Interferon-alpha-induced gene expression: evidence for a selective effect of ouabain on activation of the ISGF3 transcription complex. Nakagawa, Y., Petricoin, E.F., Akai, H., Grimley, P.M., Rupp, B., Larner, A.C. Virology (1992)
- IFN-gamma activates the C3G/Rap1 signaling pathway. Alsayed, Y., Uddin, S., Ahmad, S., Majchrzak, B., Druker, B.J., Fish, E.N., Platanias, L.C. J. Immunol. (2000)
- Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer. Slebos, R.J., Evers, S.G., Wagenaar, S.S., Rodenhuis, S. Br. J. Cancer (1989)
- Complete sequencing of the murine USF gene and comparison of its genomic organization to that of mFIP/USF2. Aperlo, C., Boulukos, K.E., Sage, J., Cuzin, F., Pognonec, P. Genomics (1996)
- Expression, purification, and characterization of the E1 for human NEDD8, the heterodimeric APPBP1-UBA3 complex. Huang, D.T., Schulman, B.A. Meth. Enzymol. (2005)
- Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. Maxwell, M., Naber, S.P., Wolfe, H.J., Galanopoulos, T., Hedley-Whyte, E.T., Black, P.M., Antoniades, H.N. J. Clin. Invest. (1990)
- p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases. Quian, X.L., Decker, S.J., Greene, M.I. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Chen, J., Fujii, K., Zhang, L., Roberts, T., Fu, H. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Bone marrow-derived osteoclast-like cells from a patient with craniometaphyseal dysplasia lack expression of osteoclast-reactive vacuolar proton pump. Yamamoto, T., Kurihara, N., Yamaoka, K., Ozono, K., Okada, M., Yamamoto, K., Matsumoto, S., Michigami, T., Ono, J., Okada, S. J. Clin. Invest. (1993)
- Quantitation of Harvey ras p21 enhanced expression in human breast and colon carcinomas. Hand, P.H., Vilasi, V., Thor, A., Ohuchi, N., Schlom, J. J. Natl. Cancer Inst. (1987)
- Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Tronick, S.R., Popescu, N.C., Cheah, M.S., Swan, D.C., Amsbaugh, S.C., Lengel, C.R., DiPaolo, J.A., Robbins, K.C. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Nucleotide sequence of the human N-myc gene. Stanton, L.W., Schwab, M., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (1986)