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Gene Review

CCNT2  -  cyclin T2

Homo sapiens

Synonyms: CycT2, Cyclin-T2
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High impact information on CCNT2

  • Granulin bound to the histidine-rich domain of cyclin T1, which was recently found to bind to the CTD, but not to cyclin T2 [1].
  • These data suggest that, in logarithmically growing cells, cdk9/cyclin T2 and pRb are located in a nuclear multiprotein complex probably involved in transduction of cellular signals to the basal transcription machinery and that one of these signals could be the cdk9 phosphorylation of pRb [2].

Anatomical context of CCNT2


  1. The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Hoque, M., Young, T.M., Lee, C.G., Serrero, G., Mathews, M.B., Pe'ery, T. Mol. Cell. Biol. (2003) [Pubmed]
  2. Physical interaction between pRb and cdk9/cyclinT2 complex. Simone, C., Bagella, L., Bellan, C., Giordano, A. Oncogene (2002) [Pubmed]
  3. Cyclin T: three forms for different roles in physiological and pathological functions. De Luca, A., De Falco, M., Baldi, A., Paggi, M.G. J. Cell. Physiol. (2003) [Pubmed]
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