Gene Review:
CDK9 - cyclin-dependent kinase 9
Homo sapiens
Synonyms:
C-2K, C-2k, CDC2L4, CTK1, Cell division cycle 2-like protein kinase 4, ...
- The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Yang, Z., Zhu, Q., Luo, K., Zhou, Q. Nature (2001)
- CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. Garber, M.E., Mayall, T.P., Suess, E.M., Meisenhelder, J., Thompson, N.E., Jones, K.A. Mol. Cell. Biol. (2000)
- Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells. Shan, B., Zhuo, Y., Chin, D., Morris, C.A., Morris, G.F., Lasky, J.A. J. Biol. Chem. (2005)
- The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. Fujinaga, K., Cujec, T.P., Peng, J., Garriga, J., Price, D.H., Graña, X., Peterlin, B.M. J. Virol. (1998)
- Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size. Sano, M., Schneider, M.D. Cell Cycle (2003)
- A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Wei, P., Garber, M.E., Fang, S.M., Fischer, W.H., Jones, K.A. Cell (1998)
- Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Sano, M., Abdellatif, M., Oh, H., Xie, M., Bagella, L., Giordano, A., Michael, L.H., DeMayo, F.J., Schneider, M.D. Nat. Med. (2002)
- 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nguyen, V.T., Kiss, T., Michels, A.A., Bensaude, O. Nature (2001)
- Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Zhou, M., Halanski, M.A., Radonovich, M.F., Kashanchi, F., Peng, J., Price, D.H., Brady, J.N. Mol. Cell. Biol. (2000)
- Differential effects on HIV replication and T cell activation following direct inhibition of CDK9 or flavopiridol (FVP) treatment in primary peripheral blood lymphocytes. Salerno, D., Hasham, M., Marshall, R., Garriga, J., Tsygankov, A., Graña, X. Retrovirology (2006)
- Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors. De Falco, G., Bellan, C., D'Amuri, A., Angeloni, G., Leucci, E., Giordano, A., Leoncini, L. Cancer Biol. Ther. (2005)
- CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. Pirngruber, J., Shchebet, A., Schreiber, L., Shema, E., Minsky, N., Chapman, R.D., Eick, D., Aylon, Y., Oren, M., Johnsen, S.A. EMBO. Rep. (2009)
- CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2. Garriga, J., Bhattacharya, S., Calbó, J., Marshall, R.M., Truongcao, M., Haines, D.S., Graña, X. Mol. Cell. Biol. (2003)
- Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes. Marshall, R.M., Salerno, D., Garriga, J., Graña, X. J. Immunol. (2005)
- Cyclin T: three forms for different roles in physiological and pathological functions. De Luca, A., De Falco, M., Baldi, A., Paggi, M.G. J. Cell. Physiol. (2003)
- Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages. Rice, A.P., Herrmann, C.H. Current HIV research. (2003)
- Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines. Ghose, R., Liou, L.Y., Herrmann, C.H., Rice, A.P. J. Virol. (2001)
- Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Kim, Y.K., Bourgeois, C.F., Isel, C., Churcher, M.J., Karn, J. Mol. Cell. Biol. (2002)
- Tax Interacts with P-TEFb in a Novel Manner To Stimulate Human T-Lymphotropic Virus Type 1 Transcription. Zhou, M., Lu, H., Park, H., Wilson-Chiru, J., Linton, R., Brady, J.N. J. Virol. (2006)
- CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization. Napolitano, G., Licciardo, P., Carbone, R., Majello, B., Lania, L. J. Cell. Physiol. (2002)
- Mechanism of H-8 inhibition of cyclin-dependent kinase 9: study using inhibitor-immobilized matrices. Shima, D., Yugami, M., Tatsuno, M., Wada, T., Yamaguchi, Y., Handa, H. Genes Cells (2003)
- Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines. Falco, G.D., Neri, L.M., Falco, M.D., Bellan, C., Yu, Z., Luca, A.D., Leoncini, L., Giordano, A. Oncogene (2002)
- Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. Fu, T.J., Peng, J., Lee, G., Price, D.H., Flores, O. J. Biol. Chem. (1999)
- Upregulation of cyclin T1/CDK9 complexes during T cell activation. Garriga, J., Peng, J., Parreño, M., Price, D.H., Henderson, E.E., Graña, X. Oncogene (1998)
- Cellular control of gene expression by T-type cyclin/CDK9 complexes. Garriga, J., Graña, X. Gene (2004)
- Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation. Lee, D.K., Duan, H.O., Chang, C. J. Biol. Chem. (2001)
- Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9. Pirngruber, J., Johnsen, S.A. Oncogene. (2010)
- Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences. Bourgeois, C.F., Kim, Y.K., Churcher, M.J., West, M.J., Karn, J. Mol. Cell. Biol. (2002)
- Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome. Kiernan, R.E., Emiliani, S., Nakayama, K., Castro, A., Labbé, J.C., Lorca, T., Nakayama Ki, K., Benkirane, M. Mol. Cell. Biol. (2001)
- The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9. Lavoie, S.B., Albert, A.L., Handa, H., Vincent, M., Bensaude, O. J. Mol. Biol. (2001)
- CDC2-related kinase PITALRE phosphorylates pRb exclusively on serine and is widely expressed in human tissues. De Luca, A., Esposito, V., Baldi, A., Claudio, P.P., Fu, Y., Caputi, M., Pisano, M.M., Baldi, F., Giordano, A. J. Cell. Physiol. (1997)
- Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop. Wang, Y., Dow, E.C., Liang, Y.Y., Ramakrishnan, R., Liu, H., Sung, T.L., Lin, X., Rice, A.P. J. Biol. Chem. (2008)
- Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Kanazawa, S., Okamoto, T., Peterlin, B.M. Immunity (2000)
- AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9. Cai, D., Byth, K.F., Shapiro, G.I. Cancer Res. (2006)
- Cdk9 phosphorylates p53 on serine 392 independently of CKII. Claudio, P.P., Cui, J., Ghafouri, M., Mariano, C., White, M.K., Safak, M., Sheffield, J.B., Giordano, A., Khalili, K., Amini, S., Sawaya, B.E. J. Cell. Physiol. (2006)
- HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription. Caldwell, R.L., Lane, K.B., Shepherd, V.L. Arch. Biochem. Biophys. (2006)
- Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. Michels, A.A., Fraldi, A., Li, Q., Adamson, T.E., Bonnet, F., Nguyen, V.T., Sedore, S.C., Price, J.P., Price, D.H., Lania, L., Bensaude, O. EMBO J. (2004)
- Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. Ramanathan, Y., Rajpara, S.M., Reza, S.M., Lees, E., Shuman, S., Mathews, M.B., Pe'ery, T. J. Biol. Chem. (2001)
- Regulation of P-TEFb elongation complex activity by CDK9 acetylation. Fu, J., Yoon, H.G., Qin, J., Wong, J. Mol. Cell. Biol. (2007)
- Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation. Isel, C., Karn, J. J. Mol. Biol. (1999)
- CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation. Bellan, C., De Falco, G., Lazzi, S., Micheli, P., Vicidomini, S., Schürfeld, K., Amato, T., Palumbo, A., Bagella, L., Sabattini, E., Bartolommei, S., Hummel, M., Pileri, S., Tosi, P., Leoncini, L., Giordano, A. J. Pathol. (2004)
- Genomic organization and characterization of promoter function of the human CDK9 gene. Liu, H., Rice, A.P. Gene (2000)
- Expression, purification, and circular dichroism analysis of human CDK9. Leopoldino, A.M., Canduri, F., Cabral, H., Junqueira, M., de Marqui, A.B., Apponi, L.H., da Fonseca, I.O., Domont, G.B., Santos, D.S., Valentini, S., Bonilla-Rodriguez, G.O., Fossey, M.A., de Azevedo, W.F., Tajara, E.H. Protein Expr. Purif. (2006)
- Cloning of murine CDK9/PITALRE and its tissue-specific expression in development. Bagella, L., MacLachlan, T.K., Buono, R.J., Pisano, M.M., Giordano, A., De Luca, A. J. Cell. Physiol. (1998)