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Gene Review

SHF  -  Src homology 2 domain containing F

Homo sapiens

Synonyms: SH2 domain-containing adapter protein F

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Protein Structure

  • SHF contains a unstructured N-terminal region containing multiple Y-x-x-P motifs and a C-terminus SH2 domain.


Protein Family

  • SHF belongs to a protein family consisting of 3 other family members: SHB, SHD, and SHE [1].








  1. The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Liu, B.A., Jablonowski, K., Raina, M., Arcé, M., Pawson, T., Nash, P.D. Mol. Cell. (2006) [Pubmed]
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