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Gene Review

SHD  -  Src homology 2 domain containing...

Homo sapiens

Synonyms: SH2 domain-containing adapter protein D
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Disease relevance of SHD

  • By comparing the C-terminal part of these proteins, we defined a novel protein domain, which we termed SHD for "StAR Homology Domain". Of the 93 primary invasive breast carcinomas that were examined, 14 were found to over-express MLN64 [1].
  • In this study, we compare a daily with a standard 3 times/week dialysis rhythm (DHD and SHD, respectively) in correcting some protein glycation indices in end-stage renal disease (ESRD) patients [2].
  • The results indicate that SHD 386L is likely to be protective to the skeleton through inhibition of bone resorption and that such actions are attributable to the estrogen component [3].
  • Patients were divided into those with (SHD) and without structural heart disease (NSHD) [4].
  • Intra-dialysis hypotension episodes did not differentiate between SHD and DHD [5].

Psychiatry related information on SHD

  • CLINICAL IMPLICATIONS: Patients with SHD may not be able to adapt their cardiac performance to an emotional stress such as a dental appointment, while it seems to be easier for MHD and TRAN patients [6].

High impact information on SHD

  • We further found that WAVE isoforms localized at the filopodial tips through SHD (SCAR homology domain), next to its leucine zipper-like motif [7].
  • Diabetic patients on SHD showed similar levels of glycation indexes as non-diabetic patients, except for the early product furosine that was notably higher [2].
  • FVII activity increased in both groups, achieving statistical significance (P less than 0.01) by cycle 6 in the SHD 415G group but not in the females receiving Logynon [8].
  • Subjects received either Logynon (ethinyl oestradiol and Levonorgestrol, n = 14) or SHD 415G (Schering U.K., n = 12), which contains a similar dosage of ethinyl oestradiol, but in combination with a new progestogen, gestodene [8].
  • Intact PTH did not change in SHD, but decreased in DHD and LNHD [9].

Biological context of SHD

  • We have also used a high-resolution image transferring system, such as SHD (2000 pixelsx2000 pixels resolution) system on one side, and an economical telemedicine system using JAVA and a WWW browser (NCC_image) on the other side [10].
  • In contrast, in SHD patients, stable 24-h blood pressure and reduction in LVMI were achieved on the expense of an increasing amount of antihypertensive medication and with worsening of FS [9].
  • The above biochemical evidence for skeletal protection will require to be supplemented by prospective biophysical evidence of the effect of SHD 386L on bone mineral density [3].
  • Short term effects of SHD 386L and levonorgestrel on bone and mineral metabolism in the postmenopause: a double-blind randomised placebo-controlled trial [3].
  • The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women [11].

Anatomical context of SHD


Associations of SHD with chemical compounds

  • The pre-dialysis level of protein-linked pentosidine was significantly lower in DHD than in SHD (DHD = 16.12 +/- 4.71 pmol/mg protein, SHD = 22.64 +/- 6.86 pmol/mg protein, p < 0.01) [13].

Other interactions of SHD

  • EPO resistance index fell in LNHD, but increased in DHD and SHD [9].
  • Managing TRAN patients is relatively easier than managing SHD patients [6].
  • This paper discusses how we devised an integrated environment for managing and operating distributed an SHD image database to support Telemedicine linking with ATM, with INS-1500, and with dial-up IP connection [14].

Analytical, diagnostic and therapeutic context of SHD

  • METHODS: We evaluated 10 non-diabetic patients on standard hemodialysis (SHD = 3 x 4 h/week) for more than 6 months by a crossover study [13].
  • Forty-five healthy postmenopausal women participated in a study designed to examine the effects on bone and mineral metabolism of SHD 386L, a new hormone replacement therapy (HRT) regime [3].
  • Patients not willing to change their dialysis regime were asked to participate as control group (SHD) [9].
  • BACKGROUND: Despite increasing numbers of patients receiving hemodialysis in satellite units (SHD), the economic aspects have not been widely explored [15].
  • At the end of 6 months of SHD and 6 months of DHD in a sequence of randomly assigned 24-hour ambulatory BP monitoring, echocardiography and bioimpedance were performed [16].


  1. MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas. Moog-Lutz, C., Tomasetto, C., Régnier, C.H., Wendling, C., Lutz, Y., Muller, D., Chenard, M.P., Basset, P., Rio, M.C. Int. J. Cancer (1997) [Pubmed]
  2. Daily haemodialysis improves indices of protein glycation. Floridi, A., Antolini, F., Galli, F., Fagugli, R.M., Floridi, E., Buoncristiani, U. Nephrol. Dial. Transplant. (2002) [Pubmed]
  3. Short term effects of SHD 386L and levonorgestrel on bone and mineral metabolism in the postmenopause: a double-blind randomised placebo-controlled trial. Purdie, D.W., Hay, A.W., Everett, M. Maturitas. (1992) [Pubmed]
  4. Changes in autonomic activity and ventricular repolarization. Shusterman, V., Beigel, A., Shah, S.I., Aysin, B., Weiss, R., Gottipaty, V.K., Schwartzman, D., Anderson, K.P. Journal of electrocardiology. (1999) [Pubmed]
  5. Effects of short daily hemodialysis and extended standard hemodialysis on blood pressure and cardiac hypertrophy: a comparative study. Fagugli, R.M., Pasini, P., Pasticci, F., Ciao, G., Cicconi, B., Buoncristiani, U. J. Nephrol. (2006) [Pubmed]
  6. Circulatory dynamics during dental extractions in normal, cardiac and transplant patients. Montebugnoli, L., Prati, C. Journal of the American Dental Association (1939) (2002) [Pubmed]
  7. Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone. Nozumi, M., Nakagawa, H., Miki, H., Takenawa, T., Miyamoto, S. J. Cell. Sci. (2003) [Pubmed]
  8. A comparison of the effects of two triphasic oral contraceptives on haemostasis. Cohen, H., Mackie, I.J., Walshe, K., Gillmer, M.D., Machin, S.J. Br. J. Haematol. (1988) [Pubmed]
  9. Effects of an increase in time vs. frequency on cardiovascular parameters in chronic hemodialysis patients. Weinreich, T., De los R??os, T., Gauly, A., Passlick-Deetjen, J. Clin. Nephrol. (2006) [Pubmed]
  10. Japanese experience of telemedicine in oncology. Mizushima, H., Uchiyama, E., Nagata, H., Matsuno, Y., Sekiguchi, R., Ohmatsu, H., Hojo, F., Shimoda, T., Wakao, F., Shinkai, T., Yamaguchi, N., Moriyama, N., Kakizoe, T., Abe, K., Terada, M. International journal of medical informatics. (2001) [Pubmed]
  11. Metabolic investigations with Femodene--an oral contraceptive containing gestodene and ethinyloestradiol. Fotherby, K., Trayner, I., Longthorne, P.N., Lee, B., Watson, H.R. Contraception. (1987) [Pubmed]
  12. Studies on conformational transitions of Ca2+, Mg2+-adenosine triphosphatase of sarcoplasmic reticulum. I. Selective labeling of functionally distinct sulfhydryl groups with conformational probes and evidence for a Ca2+-dependent conformational change. Yasuoka-Yabe, K., Kawakita, M. J. Biochem. (1983) [Pubmed]
  13. Advanced glycation end products: specific fluorescence changes of pentosidine-like compounds during short daily hemodialysis. Fagugli, R.M., Vanholder, R., De Smet, R., Selvi, A., Antolini, F., Lameire, N., Floridi, A., Buoncristiani, U. The International journal of artificial organs. (2001) [Pubmed]
  14. Design of an SHD-distributed database over IP to support telemedicine. Juzoji, H., Nakajima, I., Hata, M., Tanabe, K. Journal of medical systems. (2001) [Pubmed]
  15. The marginal cost of satellite versus in-center hemodialysis. Soroka, S.D., Kiberd, B.A., Jacobs, P. Hemodialysis international. International Symposium on Home Hemodialysis (2005) [Pubmed]
  16. Short daily hemodialysis: blood pressure control and left ventricular mass reduction in hypertensive hemodialysis patients. Fagugli, R.M., Reboldi, G., Quintaliani, G., Pasini, P., Ciao, G., Cicconi, B., Pasticci, F., Kaufman, J.M., Buoncristiani, U. Am. J. Kidney Dis. (2001) [Pubmed]
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