Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Shf - Src homology 2 domain containing F

Mus musculus

Synonyms: SH2 domain-containing adapter protein F

Lindholm, C.K. et al., Van Stry, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Shf

Other effectors of PDGFRalpha signaling, Shf, SHP-2, and Crk, are not required for this process [1].
NIH3T3 cells overexpressing Shf displayed significantly lower rates of apoptosis than control cells in the presence of PDGF-AA [2].
Shf contains an SH2 domain and four putative tyrosine phosphorylation sites and is mainly expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine, and colon [2].
Pervanadate induced tyrosine phosphorylation of Shf in NIH3T3 fibroblasts overexpressing this protein, whereas PDGF-AA alone had no detectable effect [2].
A Shb-like protein was found which we have named Shf [2].

References

Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis. Van Stry, M., Kazlauskas, A., Schreiber, S.L., Symes, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. Lindholm, C.K., Frantz, J.D., Shoelson, S.E., Welsh, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SHF	Bos taurus
SHF	Canis lupus familiaris
si:ch73-116f3.3	Danio rerio
SHF	Gallus gallus
SHF	Homo sapiens
LOC713183	Macaca mulatta
SHF	Pan troglodytes
Shf	Rattus norvegicus
shf	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share