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Gene Review

VP30  -  minor nucleoprotein

Zaire ebolavirus

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Disease relevance of VP30

  • In contrast to MBGV, EBOV-specific transcription was dependent on the presence of the fourth nucleocapsid protein, VP30 [1].

High impact information on VP30

  • While it was not possible to rescue recombinant MARV when the VP30 plasmid was omitted from transfection, MARV VP30 with a destroyed Zn-binding motif and EBOV VP30 were able to mediate virus recovery [2].

Analytical, diagnostic and therapeutic context of VP30


  1. Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems. Mühlberger, E., Weik, M., Volchkov, V.E., Klenk, H.D., Becker, S. J. Virol. (1999) [Pubmed]
  2. Rescue of recombinant Marburg virus from cDNA is dependent on nucleocapsid protein VP30. Enterlein, S., Volchkov, V., Weik, M., Kolesnikova, L., Volchkova, V., Klenk, H.D., Mühlberger, E. J. Virol. (2006) [Pubmed]
  3. A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire. Boehmann, Y., Enterlein, S., Randolf, A., Mühlberger, E. Virology (2005) [Pubmed]
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