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Gene Review:

ECs1915 - fumarate/nitrate reduction transcriptional...

Escherichia coli O157:H7 str. Sakai

Ralph, E.T. et al., Stuchlík, S. et al., Tully, R.E. et al., Popescu, C.V. et al.

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Disease relevance of ECs1915

Mössbauer spectroscopy as a tool for the study of activation/inactivation of the transcription regulator FNR in whole cells of Escherichia coli [1].
The fnr gene was cloned from its initiation codon ATG into the NdeI site of an expression vector and filamentous phage mGP1-2 was used as a donor of T7 RNA polymerase gene [2].

High impact information on ECs1915

Here, it is reported that single base substitutions in the fnr gene encoding the oxygen-responsive transcription regulator FNR (fumarate and nitrate reduction regulator) are sufficient to confer a hemolytic phenotype on E. coli K12, the widely used laboratory strain [3].
The 5' end of the mRNA transcript is 38-39 nucleotides downstream from the center of a motif that bears sequence homology to bacterial fnr promoters [4].

References

Mössbauer spectroscopy as a tool for the study of activation/inactivation of the transcription regulator FNR in whole cells of Escherichia coli. Popescu, C.V., Bates, D.M., Beinert, H., Münck, E., Kiley, P.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Overexpression of the FNR protein of Escherichia coli with T7 expression system. Stuchlík, S., Turna, J. Folia Microbiol. (Praha) (1998) [Pubmed]
Altering the anaerobic transcription factor FNR confers a hemolytic phenotype on Escherichia coli K12. Ralph, E.T., Guest, J.R., Green, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Identification and sequencing of a cytochrome P450 gene cluster from Bradyrhizobium japonicum. Tully, R.E., van Berkum, P., Lovins, K.W., Keister, D.L. Biochim. Biophys. Acta (1998) [Pubmed]

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