Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ECs4939 - peptidase E

Escherichia coli O157:H7 str. Sakai

Campoy, S. et al., Richter, R. et al., Lu, J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ECs4939

According to this, the expression of two cAMP-regulated genes, such as pepE (encoding an alpha-aspartyl dipeptidase) and the Escherichia coli lac operon, is decreased in S. typhimurium fur cells in comparison with wild-type cells [1].

High impact information on ECs4939

Based on inhibitor sensitivity and primary sequence, cyanophycinase appears to be a serine-type exopeptidase related to dipeptidase E [Conlin, C.A., Haakensson, K., Liljas, A. & Miller, C.G. (1994) J. Bacteriol. 176, 166-172] [2].
Studies on the amino acid residues of the active site of alpha-aspartyl dipeptidase [3].

References

Intracellular cyclic AMP concentration is decreased in Salmonella typhimurium fur mutants. Campoy, S., Jara, M., Busquets, N., de Rozas, A.M., Badiola, I., Barbé, J. Microbiology (Reading, Engl.) (2002) [Pubmed]
Cyanophycinase, a peptidase degrading the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartic acid (cyanophycin): molecular cloning of the gene of Synechocystis sp. PCC 6803, expression in Escherichia coli, and biochemical characterization of the purified enzyme. Richter, R., Hejazi, M., Kraft, R., Ziegler, K., Lockau, W. Eur. J. Biochem. (1999) [Pubmed]
Studies on the amino acid residues of the active site of alpha-aspartyl dipeptidase. Lu, J., Zhang, J., Zhang, H., Hao, S. Ann. N. Y. Acad. Sci. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.