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Gene Review:

argC - N-acetyl-gamma-glutamyl-phosphate reductase

Escherichia coli O157:H7 str. Sakai

Miura-Ohnuma, J. et al., Ludovice, M. et al.

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Disease relevance of ECs4887

The argC gene of Streptomyces clavuligerus encoding N-acetylglutamyl-phosphate reductase (AGPR) has been cloned by complementation of argC mutants Streptomyces lividans 1674 and Escherichia coli XC33 [1].
AGPR from Oryza sativa (OsAGPR) was expressed in Escherichia coli at 291 K as a soluble fusion protein with an upstream thioredoxin-hexahistidine [Trx-(His)6] extension [2].

High impact information on ECs4887

Formation of AGPR is repressed by addition of arginine to the culture medium [1].
N-Acetyl-gamma-glutamyl-phosphate reductase (AGPR) catalyzes the third step in an eight-step arginine-biosynthetic pathway that starts with glutamate [2].

Analytical, diagnostic and therapeutic context of ECs4887

Improved expression, purification and crystallization of a putative N-acetyl-gamma-glutamyl-phosphate reductase from rice (Oryza sativa) [2].

References

Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production. Ludovice, M., Martin, J.F., Carrachas, P., Liras, P. J. Bacteriol. (1992) [Pubmed]
Improved expression, purification and crystallization of a putative N-acetyl-gamma-glutamyl-phosphate reductase from rice (Oryza sativa). Miura-Ohnuma, J., Nonaka, T., Katoh, S., Murata, K., Kita, A., Miki, K., Katoh, E. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]

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