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Gene Review:

dapA - dihydrodipicolinate synthase

Escherichia coli O157:H7 str. Sakai

Kefala, G. et al., Pearce, F.G. et al.

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Disease relevance of dapA

Dihydrodipicolinate synthase from Thermotoga maritima [1].
Dihydrodipicolinate synthase from Mycobacterium tuberculosis (DHDPS, DapA, Rv2753c) has been cloned, heterologously expressed in Escherichia coli, purified using standard chromatographic techniques and crystallized in a monoclinic crystal form [2].

High impact information on dapA

DHDPS (dihydrodipicolinate synthase) catalyses the branch point in lysine biosynthesis in bacteria and plants and is feedback inhibited by lysine [1].

References

Dihydrodipicolinate synthase from Thermotoga maritima. Pearce, F.G., Perugini, M.A., McKerchar, H.J., Gerrard, J.A. Biochem. J. (2006) [Pubmed]
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapA (Rv2753c) from Mycobacterium tuberculosis. Kefala, G., Weiss, M.S. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]

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