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Gene Review:

ECs0598 - EnvY

Escherichia coli O157:H7 str. Sakai

Nicholson, E.B. et al., Lundrigan, M.D. et al., Klaasen, P. et al.

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Disease relevance of ECs0598

The predicted UreR amino acid sequence contains a potential helix-turn-helix motif and an associated AraC family signature and is similar to that predicted for a number of DNA-binding proteins, including E. coli proteins that regulate acid phosphatase synthesis (AppY), porin synthesis (EnvY), and rhamnose utilization (RhaR) [1].

High impact information on ECs0598

The gene product, FapR, possesses similarity to a number of positive regulators of gene expression: VirF, Rns, AppY and EnvY [2].
The EnvY protein was synthesized in minicells in greater amounts at 27 degrees C than at 37 degrees C, and a reducing agent was necessary in the solubilization buffer for its subsequent detection on polyacrylamide gels [3].

References

Proteus mirabilis urease: transcriptional regulation by UreR. Nicholson, E.B., Concaugh, E.A., Foxall, P.A., Island, M.D., Mobley, H.L. J. Bacteriol. (1993) [Pubmed]
Characterization of FapR, a positive regulator of expression of the 987P operon in enterotoxigenic Escherichia coli. Klaasen, P., de Graaf, F.K. Mol. Microbiol. (1990) [Pubmed]
Gene envY of Escherichia coli K-12 affects thermoregulation of major porin expression. Lundrigan, M.D., Earhart, C.F. J. Bacteriol. (1984) [Pubmed]

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