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Gene Review:

KCNAB3 - potassium channel, voltage gated subfamily...

Homo sapiens

Synonyms: AKR6A9, K(+) channel subunit beta-3, KCNA3.1B, KCNA3B, KV-BETA-3, ...

Morales, M.J. et al., Leicher, T. et al., McCormack, K. et al.

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High impact information on KCNAB3

The human KCNA3B sequence does not contain a mouse Kvbeta4-like open reading frame [1].
Identification of sequence-tagged sites in the gene mapped KCNA3B to band p13.1 of human chromosome 17 [1].
The Kv beta 3 transcript was found in many tissues, but was most abundant in aorta and left ventricle of the heart [2].
Mammalian voltage-activated Shaker K+ channels associate with at least three cytoplasmic proteins: Kv beta 1, Kv beta 2 and Kv beta 3 [3].

Biological context of KCNAB3

The cDNA, designated Kv beta 3, has a 408-amino acid open reading frame [2].

References

Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. Leicher, T., Bähring, R., Isbrandt, D., Pongs, O. J. Biol. Chem. (1998) [Pubmed]
A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. Morales, M.J., Castellino, R.C., Crews, A.L., Rasmusson, R.L., Strauss, H.C. J. Biol. Chem. (1995) [Pubmed]
Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. McCormack, K., McCormack, T., Tanouye, M., Rudy, B., Stühmer, W. FEBS Lett. (1995) [Pubmed]

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