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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sequence Tagged Sites

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Disease relevance of Sequence Tagged Sites


High impact information on Sequence Tagged Sites

  • Most of the 132 Y chromosomal loci mapped were sequence-tagged sites, detected by means of the polymerase chain reaction [4].
  • By using a radiation hybrid cell line panel, the PPNOC gene was mapped to the short arm of human chromosome 8 (8p21), between sequence-tagged site markers WI-5833 and WI-1172, in close proximity of the locus encoding the neurofilament light chain NEFL [5].
  • One of the mini-chromosomes is about 7 Mb in size and sequence-tagged site analysis of this molecule suggests that it corresponds to a simple truncation of the short arm of the Y chromosome [6].
  • Construction of an approximately 4 Mb YAC contig of this region identified multiple sequence tagged sites (STSs) present at both BP2 and BP3, suggestive of a genomic duplication event [7].
  • By sequence-tagged site content analysis and long range mapping we determined that one unstable transgenic line has integrated an approximately 70 kb segment of the AR locus due to fragmentation of the AR YAC [8].

Biological context of Sequence Tagged Sites


Anatomical context of Sequence Tagged Sites


Associations of Sequence Tagged Sites with chemical compounds


Gene context of Sequence Tagged Sites


Analytical, diagnostic and therapeutic context of Sequence Tagged Sites


  1. Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis. Wallrapp, C., Hähnel, S., Boeck, W., Soder, A., Mincheva, A., Lichter, P., Leder, G., Gansauge, F., Sorio, C., Scarpa, A., Gress, T.M. Int. J. Cancer (2001) [Pubmed]
  2. Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. Marigo, V., Roberts, D.J., Lee, S.M., Tsukurov, O., Levi, T., Gastier, J.M., Epstein, D.J., Gilbert, D.J., Copeland, N.G., Seidman, C.E. Genomics (1995) [Pubmed]
  3. Screening for deletions in interval D16-22 of the Y chromosome in azoospermic and oligozoospermic Japanese men. Kato, H., Komori, S., Nakata, Y., Sakata, K., Kanazawa, R., Handa, M., Kobayashi, S., Koyama, K., Isojima, S. J. Hum. Genet. (2001) [Pubmed]
  4. The human Y chromosome: a 43-interval map based on naturally occurring deletions. Vollrath, D., Foote, S., Hilton, A., Brown, L.G., Beer-Romero, P., Bogan, J.S., Page, D.C. Science (1992) [Pubmed]
  5. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Mollereau, C., Simons, M.J., Soularue, P., Liners, F., Vassart, G., Meunier, J.C., Parmentier, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage. Heller, R., Brown, K.E., Burgtorf, C., Brown, W.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Large genomic duplicons map to sites of instability in the Prader-Willi/Angelman syndrome chromosome region (15q11-q13). Christian, S.L., Fantes, J.A., Mewborn, S.K., Huang, B., Ledbetter, D.H. Hum. Mol. Genet. (1999) [Pubmed]
  8. Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability. La Spada, A.R., Peterson, K.R., Meadows, S.A., McClain, M.E., Jeng, G., Chmelar, R.S., Haugen, H.A., Chen, K., Singer, M.J., Moore, D., Trask, B.J., Fischbeck, K.H., Clegg, C.H., McKnight, G.S. Hum. Mol. Genet. (1998) [Pubmed]
  9. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Green, E.D., Maffei, M., Braden, V.V., Proenca, R., DeSilva, U., Zhang, Y., Chua, S.C., Leibel, R.L., Weissenbach, J., Friedman, J.M. Genome Res. (1995) [Pubmed]
  10. A 1.7-Mb YAC contig around the human BDNF gene (11p13): integration of the physical, genetic, and cytogenetic maps in relation to WAGR syndrome. Rosier, M.F., Goguel, A.F., Martin, A., Le Paslier, D., Couillin, P., Houlgatte, R., Bernheim, A., Auffray, C., Devignes, M.D. Genomics (1994) [Pubmed]
  11. Simplified plasmid rescue of host sequences adjacent to integrated proviruses. Kurdi-Haidar, B., Friedmann, T. Gene (1996) [Pubmed]
  12. A high-resolution STS, EST, and gene-based physical map of the hereditary paraganglioma region on chromosome 11q23. Baysal, B.E., van Schothorst, E.M., Farr, J.E., James, M.R., Devilee, P., Richard, C.W. Genomics (1997) [Pubmed]
  13. Spatial arrangement of pig MHC class I sequences. Velten, F.W., Renard, C., Rogel-Gaillard, C., Vaiman, M., Chardon, P. Immunogenetics (1999) [Pubmed]
  14. High frequency of gr/gr chromosome Y deletions in consecutive oligospermic ICSI candidates. de Llanos, M., Ballescà, J.L., Gázquez, C., Margarit, E., Oliva, R. Hum. Reprod. (2005) [Pubmed]
  15. Assignment of the human skeletal muscle alpha-tropomyosin gene (TPM1) to band 15q22 by fluorescence in situ hybridization. Eyre, H., Akkari, P.A., Wilton, S.D., Callen, D.C., Baker, E., Laing, N.G. Cytogenet. Cell Genet. (1995) [Pubmed]
  16. Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3. Patel, A., Rochelle, J.M., Jones, J.M., Sumegi, J., Uhl, G.R., Seldin, M.F., Meisler, M.H., Gregor, P. Genomics (1995) [Pubmed]
  17. Genetic follow-up of male offspring born by ICSI, using a multiplex fluorescent PCR-based test for Yq deletions. Katz, M.G., Chu, B., McLachlan, R., Alexopoulos, N.I., de Kretser, D.M., Cram, D.S. Mol. Hum. Reprod. (2002) [Pubmed]
  18. Y chromosome microdeletions, in azoospermic or near-azoospermic subjects, are located in the AZFc (DAZ) subregion. Liow, S.L., Ghadessy, F.J., Ng, S.C., Yong, E.L. Mol. Hum. Reprod. (1998) [Pubmed]
  19. The Soybean Genome Database (SoyGD): a browser for display of duplicated, polyploid, regions and sequence tagged sites on the integrated physical and genetic maps of Glycine max. Shultz, J.L., Kurunam, D., Shopinski, K., Iqbal, M.J., Kazi, S., Zobrist, K., Bashir, R., Yaegashi, S., Lavu, N., Afzal, A.J., Yesudas, C.R., Kassem, M.A., Wu, C., Zhang, H.B., Town, C.D., Meksem, K., Lightfoot, D.A. Nucleic Acids Res. (2006) [Pubmed]
  20. Expression screening of a yeast artificial chromosome contig refines the location of the mouse H3a minor histocompatibility antigen gene. Zuberi, A.R., Christianson, G.J., Dave, S.B., Bradley, J.A., Roopenian, D.C. J. Immunol. (1998) [Pubmed]
  21. A 6-Mb YAC contig in Xp22.1-p22.2 spanning the DXS69E, XE59, GLRA2, PIGA, GRPR, CALB3, and PHKA2 genes. Alitalo, T., Francis, F., Kere, J., Lehrach, H., Schlessinger, D., Willard, H.F. Genomics (1995) [Pubmed]
  22. DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1. Stathakis, D.G., Lee, D., Bryant, P.J. Genomics (1998) [Pubmed]
  23. Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels. Kwiatkowski, T.J., Beaudet, A.L., Trask, B.J., Zoghbi, H.Y. Genomics (1991) [Pubmed]
  24. Ameloblastin gene (AMBN) maps within the critical region for autosomal dominant amelogenesis imperfecta at chromosome 4q21. MacDougall, M., DuPont, B.R., Simmons, D., Reus, B., Krebsbach, P., Kärrman, C., Holmgren, G., Leach, R.J., Forsman, K. Genomics (1997) [Pubmed]
  25. Functional evidence for a metastasis suppressor gene for rat prostate cancer within a 60-kilobase region on human chromosome 8p21-p12. Nihei, N., Kouprina, N., Larionov, V., Oshima, J., Martin, G.M., Ichikawa, T., Barrett, J.C. Cancer Res. (2002) [Pubmed]
  26. Molecular characterization of an intragenic minisatellite (VNTR) polymorphism in the human parathyroid hormone-related peptide gene in chromosome region 12p12.1-p11.2. Pausova, Z., Morgan, K., Fujiwara, T.M., Bourdon, J., Goltzman, D., Hendy, G.N. Genomics (1993) [Pubmed]
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