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MeSH Review

Heart Ventricles

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Disease relevance of Heart Ventricles

  • In the case of anterior infarction, myocardial salvage as assessed by imaging with technetium-99m sestamibi was 27 +/- 21 percent of the left ventricle for 22 patients in the thrombolysis group, as compared with 31 +/- 21 percent for 15 patients in the angioplasty group [1].
  • The left and right ventricles can concordantly respond to hypertrophy and increase ANF gene transcription [2].
  • To examine whether atrial natriuretic polypeptide (ANP) is released from the left ventricle in patients with dilated cardiomyopathy (DCM) we measured plasma ANP level in the aortic root (Ao), the anterior interventricular vein (AIV), the great cardiac vein (GCV), and the coronary sinus (CS) in 11 patients with DCM and 18 control subjects [3].
  • Accordingly, we assessed muscular blood flow distribution (ml/min/g, radioactive microspheres, 15 +/- 5 micron) among and within working muscle, VO2max, and arterial lactate in a rat preparation of myocardial infarction and heart failure (infarct size 36.0 +/- 3.3% of the left ventricle, n = 9), and in sham-operated animals (n = 11) [4].
  • The coronary vasoconstrictor effect of L-NMMA was attenuated significantly in the hypertrophied right and noninfarcted left ventricle of 8-week-old infarcted rats (p less than 0.01 versus sham-operated animals) but not 24 hours after induction of myocardial infarction when cardiac hypertrophy has not yet developed [5].

Psychiatry related information on Heart Ventricles


High impact information on Heart Ventricles

  • Targeted deletion of Bop in mice disrupted maturation of ventricular cardiomyocytes and interfered with formation of the right ventricle [7].
  • Previous studies have demonstrated that Hand2 is required for formation of the right ventricle of the heart and the aortic arch arteries [8].
  • Our description of the cardiac phenotype of dHAND mutant embryos is the first demonstration of a single gene controlling the formation of the mesodermally derived right ventricle and the neural crest-derived aortic arches and reveals a novel cardiogenic subprogramme for right ventricular development [9].
  • Hypertrophic cardiomyopathy is characterized by a nondilated, hypertrophied left ventricle in the absence of any overt cause [10].
  • During one year of follow-up, the end-diastolic volume of the left ventricle increased by a mean [+/- SEM] of 21 +/- 8 ml (P less than 0.02) in the placebo group, but by only 10 +/- 6 ml (P not significant) in the captopril group [11].

Chemical compound and disease context of Heart Ventricles


Biological context of Heart Ventricles


Anatomical context of Heart Ventricles


Associations of Heart Ventricles with chemical compounds


Gene context of Heart Ventricles


Analytical, diagnostic and therapeutic context of Heart Ventricles


  1. Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups. Gibbons, R.J., Holmes, D.R., Reeder, G.S., Bailey, K.R., Hopfenspirger, M.R., Gersh, B.J. N. Engl. J. Med. (1993) [Pubmed]
  2. Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy. Lee, R.T., Bloch, K.D., Pfeffer, J.M., Pfeffer, M.A., Neer, E.J., Seidman, C.E. J. Clin. Invest. (1988) [Pubmed]
  3. Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy. Yasue, H., Obata, K., Okumura, K., Kurose, M., Ogawa, H., Matsuyama, K., Jougasaki, M., Saito, Y., Nakao, K., Imura, H. J. Clin. Invest. (1989) [Pubmed]
  4. Blood flow distribution within skeletal muscle during exercise in the presence of chronic heart failure: effect of milrinone. Drexler, H., Faude, F., Höing, S., Just, H. Circulation (1987) [Pubmed]
  5. Effects of inhibition of nitric oxide formation on regional blood flow in experimental myocardial infarction. Drexler, H., Hablawetz, E., Lu, W., Riede, U., Christes, A. Circulation (1992) [Pubmed]
  6. Idiopathic left ventricular aneurysm: a clinical and pathological study of a new entity in the spectrum of cardiomyopathies. Mestroni, L., Morgera, T., Miani, D., Pinamonti, B., Sinagra, G., Tanganelli, P., Silvestri, F., Camerini, F. Postgraduate medical journal. (1994) [Pubmed]
  7. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Gottlieb, P.D., Pierce, S.A., Sims, R.J., Yamagishi, H., Weihe, E.K., Harriss, J.V., Maika, S.D., Kuziel, W.A., King, H.L., Olson, E.N., Nakagawa, O., Srivastava, D. Nat. Genet. (2002) [Pubmed]
  8. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Firulli, A.B., McFadden, D.G., Lin, Q., Srivastava, D., Olson, E.N. Nat. Genet. (1998) [Pubmed]
  9. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Srivastava, D., Thomas, T., Lin, Q., Kirby, M.L., Brown, D., Olson, E.N. Nat. Genet. (1997) [Pubmed]
  10. Calcium-antagonist receptors in the atrial tissue of patients with hypertrophic cardiomyopathy. Wagner, J.A., Sax, F.L., Weisman, H.F., Porterfield, J., McIntosh, C., Weisfeldt, M.L., Snyder, S.H., Epstein, S.E. N. Engl. J. Med. (1989) [Pubmed]
  11. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. Pfeffer, M.A., Lamas, G.A., Vaughan, D.E., Parisi, A.F., Braunwald, E. N. Engl. J. Med. (1988) [Pubmed]
  12. Non-invasive magnetic-resonance detection of creatine depletion in non-viable infarcted myocardium. Bottomley, P.A., Weiss, R.G. Lancet (1998) [Pubmed]
  13. Beta-adrenergic receptor and cyclic AMP alterations in the canine ventricular septum during long-term norepinephrine infusion: implications for hypertrophic cardiomyopathy. Raum, W.J., Laks, M.M., Garner, D., Swerdloff, R.S. Circulation (1983) [Pubmed]
  14. Studies of amiodarone during experimental myocardial infarction: beneficial effects on hemodynamics and infarct size. DeBoer, L.W., Nosta, J.J., Kloner, R.A., Braunwald, E. Circulation (1982) [Pubmed]
  15. Right ventricular ejection fraction in patients with acute anterior and inferior myocardial infarction assessed by radionuclide angiography. Tobinick, E., Schelbert, H.R., Henning, H., LeWinter, M., Taylor, A., Ashburn, W.L., Karliner, J.S. Circulation (1978) [Pubmed]
  16. Drug-induced expansion of infarct: morphologic and functional correlations. Hammerman, H., Schoen, F.J., Braunwald, E., Kloner, R.A. Circulation (1984) [Pubmed]
  17. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. Eddahibi, S., Hanoun, N., Lanfumey, L., Lesch, K.P., Raffestin, B., Hamon, M., Adnot, S. J. Clin. Invest. (2000) [Pubmed]
  18. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. Ping, P., Gelzer-Bell, R., Roth, D.A., Kiel, D., Insel, P.A., Hammond, H.K. J. Clin. Invest. (1995) [Pubmed]
  19. Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. Bristow, M.R., Minobe, W., Rasmussen, R., Larrabee, P., Skerl, L., Klein, J.W., Anderson, F.L., Murray, J., Mestroni, L., Karwande, S.V. J. Clin. Invest. (1992) [Pubmed]
  20. Morphogenesis of the right ventricle requires myocardial expression of Gata4. Zeisberg, E.M., Ma, Q., Juraszek, A.L., Moses, K., Schwartz, R.J., Izumo, S., Pu, W.T. J. Clin. Invest. (2005) [Pubmed]
  21. Modulation of drug effects by regional sympathetic denervation and supersensitivity. Stanton, M.S., Zipes, D.P. Circulation (1991) [Pubmed]
  22. Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus. Ivy, D.D., Parker, T.A., Ziegler, J.W., Galan, H.L., Kinsella, J.P., Tuder, R.M., Abman, S.H. J. Clin. Invest. (1997) [Pubmed]
  23. Ritanserin decreases portal pressure in conscious and unrestrained cirrhotic rats. Mastai, R., Giroux, L., Semret, M., Huet, P.M. Gastroenterology (1990) [Pubmed]
  24. Comparative effects of nicardipine, a new calcium antagonist, on size of myocardial infarction after coronary artery occlusion in dogs. Endo, T., Nejima, J., Fujita, S., Kiuchi, K., Iida, N., Kikuchi, K., Hayakawa, H., Okumura, H. Circulation (1986) [Pubmed]
  25. Mitral annular dilatation and papillary muscle dislocation without mitral regurgitation in sheep. Green, G.R., Dagum, P., Glasson, J.R., Daughters, G.T., Bolger, A.F., Foppiano, L.E., Berry, G.J., Ingels, N.B., Miller, D.C. Circulation (1999) [Pubmed]
  26. Regional effects of verapamil on recovery of excitability and conduction time in experimental ischemia. Kimura, S., Bassett, A.L., Kohya, T., Kozlovskis, P.L., Myerburg, R.J. Circulation (1987) [Pubmed]
  27. In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries. May, D.C., Popma, J.J., Black, W.H., Schaefer, S., Lee, H.R., Levine, B.D., Hillis, L.D. N. Engl. J. Med. (1987) [Pubmed]
  28. Left ventricular receptors inhibit brain serotonin neurons during coronary artery occlusion. Sole, M.J., Van Loon, G., Shum, A., Lixfield, W., MacGregor, D.C. Science (1978) [Pubmed]
  29. Exercise training combined with antihypertensive drug therapy. Effects on lipids, blood pressure, and left ventricular mass. Kelemen, M.H., Effron, M.B., Valenti, S.A., Stewart, K.J. JAMA (1990) [Pubmed]
  30. Decreased adrenergic neuronal uptake activity in experimental right heart failure. A chamber-specific contributor to beta-adrenoceptor downregulation. Liang, C.S., Fan, T.H., Sullebarger, J.T., Sakamoto, S. J. Clin. Invest. (1989) [Pubmed]
  31. Effects of pressure overload, left ventricular hypertrophy on beta-adrenergic receptors, and responsiveness to catecholamines. Vatner, D.E., Homcy, C.J., Sit, S.P., Manders, W.T., Vatner, S.F. J. Clin. Invest. (1984) [Pubmed]
  32. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Naya, F.J., Black, B.L., Wu, H., Bassel-Duby, R., Richardson, J.A., Hill, J.A., Olson, E.N. Nat. Med. (2002) [Pubmed]
  33. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. Yet, S.F., Perrella, M.A., Layne, M.D., Hsieh, C.M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H., Kourembanas, S., Lee, M.E. J. Clin. Invest. (1999) [Pubmed]
  34. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Ozcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C., Garratt, A.N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  35. Characterization of a voltage-gated K+ channel beta subunit expressed in human heart. England, S.K., Uebele, V.N., Shear, H., Kodali, J., Bennett, P.B., Tamkun, M.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  36. Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart. Togi, K., Kawamoto, T., Yamauchi, R., Yoshida, Y., Kita, T., Tanaka, M. Mol. Cell. Biol. (2004) [Pubmed]
  37. Cross-sectional echocardiography. II. Analysis of mathematic models for quantifying volume of the formalin-fixed left ventricle. Wyatt, H.L., Heng, M.K., Meerbaum, S., Gueret, P., Hestenes, J., Dula, E., Corday, E. Circulation (1980) [Pubmed]
  38. Global and regional left ventricular function and tomographic radionuclide perfusion: the Western Washington Intracoronary Streptokinase In Myocardial Infarction Trial. Ritchie, J.L., Davis, K.B., Williams, D.L., Caldwell, J., Kennedy, J.W. Circulation (1984) [Pubmed]
  39. Right ventricular function and metabolism. Christakis, G.T., Weisel, R.D., Mickle, D.A., Ivanov, J., Tumiati, L.C., Zuech, P.E., Madonik, M.M., Liu, P. Circulation (1990) [Pubmed]
  40. Nonuniformity of pericardial surface pressure in dogs. Smiseth, O.A., Scott-Douglas, N.W., Thompson, C.R., Smith, E.R., Tyberg, J.V. Circulation (1987) [Pubmed]
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