Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HDvgp2 - HDAg

Hepatitis delta virus

Farci, P. et al., Kojima, T. et al., Naoumov, N.V. et al., Chaggar, K. et al., Polo, J.M. et al.

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Disease relevance of HDvgp2

Delta antigen and antibody were screened for in serum of 43 patients consecutively seen in hospital, 22 with acute hepatitis B (anti-HBc IgM-positive), and 21 with histological evidence of chronic active hepatitis, 6 of whom were brothers in a sibship of eleven [1].
Lymphocytic infiltration occurred more often close to hepatocytes containing either hepatitis Delta antigen or hepatitis B core antigen in the cytoplasm, suggesting an involvement of cellular immune mechanisms in chronic hepatitis D as well as in hepatitis B [2].

High impact information on HDvgp2

Delta antigen was detected in the nuclei of myocytes [3].

Analytical, diagnostic and therapeutic context of HDvgp2

A sensitive and reproducible enzyme-linked immunoassay (ELISA) for IgA class antibodies against the Delta antigen (HDAg) is described [4].
Delta antigen was detected by direct immunofluorescence in the liver of 9 patients with chronic HBV infection (8.6%), and in 3 patients with fulminant hepatitis (7.14%) [5].

References

Delta hepatitis in Lebanon. Prevalence studies and a report on six siblings with chronic delta-positive active hepatitis. Farci, P., Burroughs, A.K., Thomas, H.C., Shamma'a, M. J. Hepatol. (1987) [Pubmed]
Immuno-light and electron microscopic features of chronic hepatitis D. Kojima, T., Callea, F., Desmyter, J., Sakurai, I., Desmet, V.J. Liver (1990) [Pubmed]
Transgenic mice support replication of hepatitis delta virus RNA in multiple tissues, particularly in skeletal muscle. Polo, J.M., Jeng, K.S., Lim, B., Govindarajan, S., Hofman, F., Sangiorgi, F., Lai, M.M. J. Virol. (1995) [Pubmed]
An enzyme immunoassay for detection of IgA class antibodies against hepatitis delta virus. Chaggar, K., McFarlane, I.G., Smith, H.M., Alexander, G.J., Williams, R. J. Virol. Methods (1991) [Pubmed]
Infection with hepatitis delta virus in patients with fulminant hepatitis B and chronic HBsAg carriers in Bulgaria. Naoumov, N.V., Gueorgiev, A., Ognyanov, M., Maleev, A. Hepatogastroenterology (1986) [Pubmed]

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