The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CDHR1  -  cadherin-related family member 1

Homo sapiens

Synonyms: CORD15, Cadherin-related family member 1, KIAA1775, PCDH21, PRCAD, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PCDH21

  • CONCLUSIONS: PCDH21 mutations are not a major cause of the retinal diseases investigated herein, and the corresponding human phenotype remains to be determined [1].
  • RESULTS: PCDH21 spans 23 kb, consists of 17 exons, and encodes a protein that shows close phylogenetic relationship to cadherin-23 (CDH23), the protein involved in Usher syndrome type 1D [1].

High impact information on PCDH21

  • In ACTH+, beside the expected POMC gene, we identified cFos, and KIAA1775, a large expressed sequence tag encoding a putative protocadherin-related protein [2].
  • Therefore we searched for a human retinal phenotype associated with mutations in the orthologous human gene, PCDH21 [1].
  • PURPOSE: It has been demonstrated that mice lacking a functional copy of prCAD, the gene encoding protocadherin-21, show progressive photoreceptor degeneration [1].


  1. Protocadherin-21 (PCDH21), a candidate gene for human retinal dystrophies. Bolz, H., Ebermann, I., Gal, A. Mol. Vis. (2005) [Pubmed]
  2. Identification of genes associated with the corticotroph phenotype in bronchial carcinoid tumors. Pascual-Le Tallec, L., Dulmet, E., Bertagna, X., de Keyzer, Y. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
WikiGenes - Universities