Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

LEMD1 - LEM domain containing 1

Homo sapiens

Synonyms: CT50, Cancer/testis antigen 50, LEM domain protein 1, LEM domain-containing protein 1, LEMP-1

Yuki, D. et al., Nichols, R.J. et al., Mansharamani, M. et al., Liu, J. et al.

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Disease relevance of LEMD1

Among the genes that were frequently transactivated in colorectal tumors, we identified a novel gene termed LEMD1 (LEM domain-containing 1) whose expression was elevated in 17 of 18 CRCs compared with their corresponding non-cancerous mucosae [1].
Since the LEMD1 protein appears to fall in the category of cancer-testis antigens (CTAs), it may represent a promising target antigen for immunotherapy of CRCs [1].

High impact information on LEMD1

Emerin and MAN1 are LEM domain-containing integral membrane proteins of the vertebrate nuclear envelope [2].
BAF binds to both DNA and LEM domain-containing proteins of the inner nuclear membrane; in lower eukaryotes, BAF has been shown to play an important role during the reassembly of the nuclear envelope at the end of mitosis [3].
MAN1 has an exposed LEM domain-containing N-terminal region ("MAN1-N"), two transmembrane domains, and an exposed C-terminal domain ("MAN1-C") [4].
Northern blotting revealed that LEMD1 was expressed only in testis among the 16 normal adult tissues examined [1].

References

Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers. Yuki, D., Lin, Y.M., Fujii, Y., Nakamura, Y., Furukawa, Y. Oncol. Rep. (2004) [Pubmed]
MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Liu, J., Lee, K.K., Segura-Totten, M., Neufeld, E., Wilson, K.L., Gruenbaum, Y. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
The Vaccinia-related Kinases Phosphorylate the N' Terminus of BAF, Regulating Its Interaction with DNA and Its Retention in the Nucleus. Nichols, R.J., Wiebe, M.S., Traktman, P. Mol. Biol. Cell (2006) [Pubmed]
Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor. Mansharamani, M., Wilson, K.L. J. Biol. Chem. (2005) [Pubmed]

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