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Gene Review:

mutX - 8-oxodGTP nucleoside triphosphatase

Streptococcus pneumoniae R6

Méjean, V. et al., Bullions, L.C. et al.

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Disease relevance of mutX

The mutX gene of Streptococcus pneumoniae, a homologue of the Escherichia coli mutT mutator gene (Méjean, V., Salles, C., Bullions, L. C., Bessman, M. J., and Claverys, J.-P. (1993) Mol. Microbiol. 11, 323-330) has been cloned into an expression vector, and its gene product, the MutX protein, has been purified to apparent homogeneity [1].
Nucleotide sequence determination reveals that the mutX gene encodes a 17,870 Da protein (154 residues) which exhibits significant homology with the MutT protein of Escherichia coli, a nucleoside triphosphatase (dGTP pyrophosphohydrolase) [2].

High impact information on mutX

Characterization of the mutX gene of Streptococcus pneumoniae as a homologue of Escherichia coli mutT, and tentative definition of a catalytic domain of the dGTP pyrophosphohydrolases [2].
The mutX gene complements the E. coli mutT mutator phenotype when introduced on a plasmid [2].
We show that deletion of a gene of Streptococcus pneumoniae, which we call mutX, confers a mutator phenotype to resistance to streptomycin [2].

References

Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity. Bullions, L.C., Méjean, V., Claverys, J.P., Bessman, M.J. J. Biol. Chem. (1994) [Pubmed]
Characterization of the mutX gene of Streptococcus pneumoniae as a homologue of Escherichia coli mutT, and tentative definition of a catalytic domain of the dGTP pyrophosphohydrolases. Méjean, V., Salles, C., Bullions, L.C., Bessman, M.J., Claverys, J.P. Mol. Microbiol. (1994) [Pubmed]

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