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Gene Review:

coiA - competence protein CoiA

Streptococcus pneumoniae R6

Desai, B.V. et al., Desai, B.V. et al., Knutsen, E. et al.

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Disease relevance of coiA

Transformation in Streptococcus pneumoniae: formation of eclipse complex in a coiA mutant implicates CoiA in genetic recombination [1].
CoiA is widely conserved among gram-positive bacteria, and in streptococci, the entire coiA locus composed of four genes is conserved [2].

High impact information on coiA

Together, these results establish that a coiA mutant exhibits a phenotype different from that of dprA or recA mutants, and that CoiA functions at a later step in promoting recombination during genetic transformation in Streptococcus pneumoniae [1].
Here we report that although the rate of DNA uptake was not affected in a coiA mutant, the internalized donor DNA did not recombine into the host chromosome to form a physical and genetic heteroduplex [1].
BOX Elements Modulate Gene Expression in Streptococcus pneumoniae: Impact on the Fine-Tuning of Competence Development [3].

References

Transformation in Streptococcus pneumoniae: formation of eclipse complex in a coiA mutant implicates CoiA in genetic recombination. Desai, B.V., Morrison, D.A. Mol. Microbiol. (2007) [Pubmed]
An unstable competence-induced protein, CoiA, promotes processing of donor DNA after uptake during genetic transformation in Streptococcus pneumoniae. Desai, B.V., Morrison, D.A. J. Bacteriol. (2006) [Pubmed]
BOX Elements Modulate Gene Expression in Streptococcus pneumoniae: Impact on the Fine-Tuning of Competence Development. Knutsen, E., Johnsborg, O., Quentin, Y., Claverys, J.P., H??varstein, L.S. J. Bacteriol. (2006) [Pubmed]

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