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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

r144  -  pr144

Murid herpesvirus 2

 
 
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Disease relevance of r144

 

High impact information on r144

  • To study the role of r144 in virus replication, an RCMV r144 null mutant strain (RCMVDeltar144) was generated [1].
  • This suggests that r144 might function in the interaction with these leukocytes in vivo [1].
  • At 21 days p.i., RCMVdelta r144-infected rats were found to have lower virus titers in the salivary glands than wt RCMV-infected animals [2].
 

Biological context of r144

  • These data indicate that the RCMV r144 gene is essential neither for virus replication in the acute phase of infection nor for long-term infection in immunocompromised rats [1].

References

  1. The r144 major histocompatibility complex class I-like gene of rat cytomegalovirus is dispensable for both acute and long-term infection in the immunocompromised host. Beisser, P.S., Kloover, J.S., Grauls, G.E., Blok, M.J., Bruggeman, C.A., Vink, C. J. Virol. (2000) [Pubmed]
  2. A rat cytomegalovirus strain with a disruption of the r144 MHC class I-like gene is attenuated in the acute phase of infection in neonatal rats. Kloover, J.S., Grauls, G.E., Blok, M.J., Vink, C., Bruggeman, C.A. Arch. Virol. (2002) [Pubmed]
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