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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Virus Replication

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Disease relevance of Virus Replication


High impact information on Virus Replication


Chemical compound and disease context of Virus Replication


Biological context of Virus Replication


Anatomical context of Virus Replication


Associations of Virus Replication with chemical compounds


Gene context of Virus Replication

  • The data also suggest that sor influences virus replication at a novel, post-translational stage and that its action is independent of the regulatory genes tat and trs [31].
  • The ability of ced-3 and ced-4 alleles to restrict virus replication is correlated with their cell-killing activities [32].
  • Virus replication is enhanced in HDAC6-depleted cells, demonstrating HDAC6 is an essential component of innate antiviral immunity [33].
  • Treatment of cells with TNF-alpha in the presence of ZVAD caused increased expression of TNF-alpha and induced enhanced virus replication [34].
  • Moreover, expression of the IRF9-STAT2 fusion can recapitulate the type I IFN biological response, producing a cellular antiviral state that protects cells from virus-induced cytopathic effects and inhibits virus replication [35].

Analytical, diagnostic and therapeutic context of Virus Replication


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  2. Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice. Guidotti, L.G., McClary, H., Loudis, J.M., Chisari, F.V. J. Exp. Med. (2000) [Pubmed]
  3. Levamisole therapy in chronic type B hepatitis. Results of a double-blind randomized trial. Fattovich, G., Brollo, L., Pontisso, P., Pornaro, E., Rugge, M., Alberti, A., Realdi, G. Gastroenterology (1986) [Pubmed]
  4. An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP. Luciano, R.L., Wilson, A.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Decreased human immunodeficiency virus type 1 plasma viremia during antiretroviral therapy reflects downregulation of viral replication in lymphoid tissue. Cohen, O.J., Pantaleo, G., Holodniy, M., Schnittman, S., Niu, M., Graziosi, C., Pavlakis, G.N., Lalezari, J., Bartlett, J.A., Steigbigel, R.T. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Hanna, Z., Kay, D.G., Rebai, N., Guimond, A., Jothy, S., Jolicoeur, P. Cell (1998) [Pubmed]
  7. Mutational analysis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression. Green, M., Ishino, M., Loewenstein, P.M. Cell (1989) [Pubmed]
  8. Activation of heat-shock response by an adenovirus is essential for virus replication. Glotzer, J.B., Saltik, M., Chiocca, S., Michou, A.I., Moseley, P., Cotten, M. Nature (2000) [Pubmed]
  9. Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR. Ventoso, I., Sanz, M.A., Molina, S., Berlanga, J.J., Carrasco, L., Esteban, M. Genes Dev. (2006) [Pubmed]
  10. Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. Zheng, S., De, B.P., Choudhary, S., Comhair, S.A., Goggans, T., Slee, R., Williams, B.R., Pilewski, J., Haque, S.J., Erzurum, S.C. Immunity (2003) [Pubmed]
  11. Lamivudine therapy for chronic hepatitis B: a six-month randomized dose-ranging study. Nevens, F., Main, J., Honkoop, P., Tyrrell, D.L., Barber, J., Sullivan, M.T., Fevery, J., De Man, R.A., Thomas, H.C. Gastroenterology (1997) [Pubmed]
  12. Inhibition of hepatitis B virus replication by vidarabine monophosphate conjugated with lactosaminated serum albumin. Fiume, L., Cerenzia, M.R., Bonino, F., Busi, C., Mattioli, A., Brunetto, M.R., Chiaberge, E., Verme, G. Lancet (1988) [Pubmed]
  13. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Heinzinger, N.K., Bukinsky, M.I., Haggerty, S.A., Ragland, A.M., Kewalramani, V., Lee, M.A., Gendelman, H.E., Ratner, L., Stevenson, M., Emerman, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Myristoylation-dependent replication and assembly of human immunodeficiency virus 1. Bryant, M., Ratner, L. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  15. Pilot study of ribavirin and interferon-beta for chronic hepatitis B. Kakumu, S., Yoshioka, K., Wakita, T., Ishikawa, T., Takayanagi, M., Higashi, Y. Hepatology (1993) [Pubmed]
  16. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. Selin, L.K., Varga, S.M., Wong, I.C., Welsh, R.M. J. Exp. Med. (1998) [Pubmed]
  17. Induction of HSP70 and polyubiquitin expression associated with plant virus replication. Aranda, M.A., Escaler, M., Wang, D., Maule, A.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  18. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Göttlinger, H.G., Sodroski, J.G., Haseltine, W.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  19. Inhibition of pathogenic SHIV replication in macaques treated with antisense DNA of interleukin-4. Dhillon, N.K., Sui, Y., Potula, R., Dhillon, S., Adany, I., Li, Z., Villinger, F., Pinson, D., Narayan, O., Buch, S. Blood (2005) [Pubmed]
  20. Efficient replication of adenovirus despite the overexpression of active and nondegradable p53. Koch, P., Gatfield, J., Löber, C., Hobom, U., Lenz-Stöppler, C., Roth, J., Dobbelstein, M. Cancer Res. (2001) [Pubmed]
  21. Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells. Lisziewicz, J., Sun, D., Weichold, F.F., Thierry, A.R., Lusso, P., Tang, J., Gallo, R.C., Agrawal, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  22. Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication. Luciw, P.A., Cheng-Mayer, C., Levy, J.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  23. Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis. Barber, S.A., Uhrlaub, J.L., DeWitt, J.B., Tarwater, P.M., Zink, M.C. Am. J. Pathol. (2004) [Pubmed]
  24. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. Bergmann, C.C., Parra, B., Hinton, D.R., Chandran, R., Morrison, M., Stohlman, S.A. J. Immunol. (2003) [Pubmed]
  25. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. Parra, B., Hinton, D.R., Marten, N.W., Bergmann, C.C., Lin, M.T., Yang, C.S., Stohlman, S.A. J. Immunol. (1999) [Pubmed]
  26. Quantitation of influenza virus antigens on infected target cells and their recognition by cross-reactive cytotoxic T cells. Hackett, C.J., Askonas, B.A., Webster, R.G., van Wyke, K. J. Exp. Med. (1980) [Pubmed]
  27. Inhibition of interferon-gamma antiviral and antiproliferative activities by ras oncogene expression. Gariglio, M., Gribaudo, G., Franco, A., Pierotti, M.A., Cavallo, G., Landolfo, S. J. Natl. Cancer Inst. (1989) [Pubmed]
  28. Cholesterol is required for infection by Semliki Forest virus. Phalen, T., Kielian, M. J. Cell Biol. (1991) [Pubmed]
  29. Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. Crowe, J.E., Murphy, B.R., Chanock, R.M., Williamson, R.A., Barbas, C.F., Burton, D.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  30. Nonpulmonary manifestations of cytomegalovirus infection in immunocompromised patients. Drew, W.L. Clin. Microbiol. Rev. (1992) [Pubmed]
  31. The sor gene of HIV-1 is required for efficient virus transmission in vitro. Fisher, A.G., Ensoli, B., Ivanoff, L., Chamberlain, M., Petteway, S., Ratner, L., Gallo, R.C., Wong-Staal, F. Science (1987) [Pubmed]
  32. Restriction of vaccinia virus replication by a ced-3 and ced-4-dependent pathway in Caenorhabditis elegans. Liu, W.H., Lin, Y.L., Wang, J.P., Liou, W., Hou, R.F., Wu, Y.C., Liao, C.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  33. Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Nusinzon, I., Horvath, C.M. Mol. Cell. Biol. (2006) [Pubmed]
  34. Caspase inhibition activates HIV in latently infected cells. Role of tumor necrosis factor receptor 1 and CD95. Scheller, C., Sopper, S., Chen, P., Flory, E., Koutsilieri, E., Racek, T., Ludwig, S., ter Meulen, V., Jassoy, C. J. Biol. Chem. (2002) [Pubmed]
  35. A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. Kraus, T.A., Lau, J.F., Parisien, J.P., Horvath, C.M. J. Biol. Chem. (2003) [Pubmed]
  36. Immunosuppression by Moloney leukemia virus: lack of correlation between virus replication and the immunosuppressive effect. Cerny, J., Proffitt, M.R., Essex, M. J. Natl. Cancer Inst. (1976) [Pubmed]
  37. L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Vacca, J.P., Dorsey, B.D., Schleif, W.A., Levin, R.B., McDaniel, S.L., Darke, P.L., Zugay, J., Quintero, J.C., Blahy, O.M., Roth, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  38. Antiretroviral resistance during successful therapy of HIV type 1 infection. Martinez-Picado, J., DePasquale, M.P., Kartsonis, N., Hanna, G.J., Wong, J., Finzi, D., Rosenberg, E., Gunthard, H.F., Sutton, L., Savara, A., Petropoulos, C.J., Hellmann, N., Walker, B.D., Richman, D.D., Siliciano, R., D'Aquila, R.T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  39. A tale of two strands: reverse-transcriptase polymerase chain reaction detection of hepatitis C virus replication. Sangar, D.V., Carroll, A.R. Hepatology (1998) [Pubmed]
  40. T-cell activation is required for efficient replication of human herpesvirus 6. Frenkel, N., Schirmer, E.C., Katsafanas, G., June, C.H. J. Virol. (1990) [Pubmed]
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