Disease relevance of tdcR

• Identification and DNA sequence of tdcR, a positive regulatory gene of the tdc operon of Escherichia coli [1].

High impact information on tdcR

• We have identified the transcription site of tdcR by primer extension mapping and established the translation start site of TdcR by mutational analysis of its reading frame [2].
• The tdcR gene is located 198 base pairs upstream of the tdc operon and is transcribed divergently from this operon [1].
• Efficient in vivo expression of the biodegradative threonine dehydratase (tdc) operon of Escherichia coli is dependent on a regulatory gene, tdcR [1].
• The nucleotide sequence of tdcR and two unrelated reading frames has been determined [1].

Biological context of tdcR

• Deletion analysis and minicell expression of the tdcR gene suggest that TdcR may serve as a trans-acting positive activator for the tdc operon [1].

References