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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LY86  -  lymphocyte antigen 86

Homo sapiens

Synonyms: Ly-86, Lymphocyte antigen 86, MD-1, MD1, MMD-1, ...
 
 
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High impact information on LY86

  • RP105 is associated with MD-1 and transmits an activation signal in human B cells [1].
  • In transient transfection of RP105, the percentage of RP105-positive cells increased more than twice with the coexpression of MD-1 [2].
  • Here, we found that BCG-CWS activates human monocytes and concomitantly down-regulates expression of a human homologue of chicken MD-1 in the activated monocytes by differential display [3].
  • According to a previous study, MD-1 forms a complex with the Toll family protein RP-105 on murine B cell lines to facilitate its stable expression [3].
 

Anatomical context of LY86

  • Thus, MD-1 may participate in regulation of innate immune activation on human monocytes [3].
 

Analytical, diagnostic and therapeutic context of LY86

  • An association of these molecules was confirmed by immunoprecipitation with the anti-RP105 Ab and subsequent probing of the epitope tag on MD-1 [2].

References

  1. RP105 is associated with MD-1 and transmits an activation signal in human B cells. Miura, Y., Shimazu, R., Miyake, K., Akashi, S., Ogata, H., Yamashita, Y., Narisawa, Y., Kimoto, M. Blood (1998) [Pubmed]
  2. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. Miyake, K., Shimazu, R., Kondo, J., Niki, T., Akashi, S., Ogata, H., Yamashita, Y., Miura, Y., Kimoto, M. J. Immunol. (1998) [Pubmed]
  3. Human MD-1 homologue is a BCG-regulated gene product in monocytes: its identification by differential display. Begum, N.A., Tsuji, S., Nomura, M., Shida, K., Azuma, I., Hayashi, A., Matsumoto, M., Seya, T., Toyoshima, K. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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