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Gene Review:

moaD - molybdopterin synthase, small subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0773, JW0767, chlM

Pitterle, D.M. et al., Jensen, P.E. et al.

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Disease relevance of moaD

Molybdopterin (MPT) is not produced by the Escherichia coli mutants chlA1, chlM, or chlN or by the Neurospora crassa mutant nit-1 [1].
Soluble extract from an E. coli strain expressing chlM converted Mg-protoporphyrin IX to Mg-protoporphyrin monomethyl ester, demonstrating that chlM encodes the Mg-protoporphyrin methyltransferase of Synechocystis [2].

High impact information on moaD

Finally, it was shown that the chlM mutant lacks the 10-kDa protein while the chlN mutant, which contains both the 10- and 25-kDa proteins, lacks a function required to activate the 10-kDa protein [1].

References

Two proteins encoded at the chlA locus constitute the converting factor of Escherichia coli chlA1. Pitterle, D.M., Rajagopalan, K.V. J. Bacteriol. (1989) [Pubmed]
Introduction of a new branchpoint in tetrapyrrole biosynthesis in Escherichia coli by co-expression of genes encoding the chlorophyll-specific enzymes magnesium chelatase and magnesium protoporphyrin methyltransferase. Jensen, P.E., Gibson, L.C., Shephard, F., Smith, V., Hunter, C.N. FEBS Lett. (1999) [Pubmed]

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