Disease relevance of moeB

• Differential effects of a molybdopterin synthase sulfurylase (moeB) mutation on Escherichia coli molybdoenzyme maturation [1].

High impact information on moeB

• Finally, it was shown that the chlM mutant lacks the 10-kDa protein while the chlN mutant, which contains both the 10- and 25-kDa proteins, lacks a function required to activate the 10-kDa protein [2].
• Both pathways, however, occur in some algae, mosses, ferns, and gymnosperms, and each chloroplast genome of these organisms contains three genes, chlL, chlN, and chlB, encoding the three subunits of light-independent protochlorophyllide reductase (LIPOR) required for protochlorophyllide reduction in the dark [3].

Analytical, diagnostic and therapeutic context of moeB

• The precursor is purified from acid extracts of cells of the Escherichia coli molybdopterin-deficient mutant chlN by reverse phase and ion exchange high performance liquid chromatography [4].

References