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Gene Review:

mukF - chromosome condensin MukBEF, kleisin-like...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0913, JW0905, kicB

Feng, J. et al., Yamanaka, K. et al., Onogi, T. et al.

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Disease relevance of mukF

Identification of two new genes, mukE and mukF, involved in chromosome partitioning in Escherichia coli [1].

High impact information on mukF

Escherichia coli mukF, mukE, and mukB null mutants have common phenotypes such as temperature-dependent colony formation, anucleate cell production, chromosome cutting by septum closure, and abnormal localization of SeqA-DNA clusters [2].

Regulatory relationships of mukF

Rates of protein synthesis, but not of RNA or DNA synthesis, fell dramatically during incubation at 42 degrees C. These results suggested that the kicB gene encodes a killing factor and the kicA gene codes for a protein that suppresses the killing function of the kicB gene product [3].

Other interactions of mukF

Here, we report that mukF and mukE null mutants are both temperature-sensitive for colony formation and produce anucleate cells even at the permissive temperature [1].

References

Identification of two new genes, mukE and mukF, involved in chromosome partitioning in Escherichia coli. Yamanaka, K., Ogura, T., Niki, H., Hiraga, S. Mol. Gen. Genet. (1996) [Pubmed]
Null mutation of the dam or seqA gene suppresses temperature-sensitive lethality but not hypersensitivity to novobiocin of muk null mutants. Onogi, T., Yamazoe, M., Ichinose, C., Niki, H., Hiraga, S. J. Bacteriol. (2000) [Pubmed]
New killing system controlled by two genes located immediately upstream of the mukB gene in Escherichia coli. Feng, J., Yamanaka, K., Niki, H., Ogura, T., Hiraga, S. Mol. Gen. Genet. (1994) [Pubmed]

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