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Gene Review

mukE  -  chromosome condensin MukBEF, MukE...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0914, JW0906, kicA, ycbA
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Disease relevance of mukE


High impact information on mukE


Biological context of mukE

  • When kicA disruptant cells bearing a temperature-sensitive replication plasmid carrying the kicA+ gene were grown at 30 degrees C and then transferred to 42 degrees C, the mutant cells gradually lost colony-forming ability, even in the presence of a mukB+ plasmid [4].

Regulatory relationships of mukE

  • Rates of protein synthesis, but not of RNA or DNA synthesis, fell dramatically during incubation at 42 degrees C. These results suggested that the kicB gene encodes a killing factor and the kicA gene codes for a protein that suppresses the killing function of the kicB gene product [4].

Other interactions of mukE

  • Here, we report that mukF and mukE null mutants are both temperature-sensitive for colony formation and produce anucleate cells even at the permissive temperature [1].
  • In null mutants for the mukF, mukE, and mukB genes, the synchronous initiation of chromosome replication was not affected [1].


  1. Identification of two new genes, mukE and mukF, involved in chromosome partitioning in Escherichia coli. Yamanaka, K., Ogura, T., Niki, H., Hiraga, S. Mol. Gen. Genet. (1996) [Pubmed]
  2. Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli. Yamazoe, M., Onogi, T., Sunako, Y., Niki, H., Yamanaka, K., Ichimura, T., Hiraga, S. EMBO J. (1999) [Pubmed]
  3. Null mutation of the dam or seqA gene suppresses temperature-sensitive lethality but not hypersensitivity to novobiocin of muk null mutants. Onogi, T., Yamazoe, M., Ichinose, C., Niki, H., Hiraga, S. J. Bacteriol. (2000) [Pubmed]
  4. New killing system controlled by two genes located immediately upstream of the mukB gene in Escherichia coli. Feng, J., Yamanaka, K., Niki, H., Ogura, T., Hiraga, S. Mol. Gen. Genet. (1994) [Pubmed]
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