Disease relevance of mukE

• Identification of two new genes, mukE and mukF, involved in chromosome partitioning in Escherichia coli [1].

High impact information on mukE

• mukF, mukE and mukB genes are essential for the process of chromosome partitioning in Escherichia coli [2].
• Escherichia coli mukF, mukE, and mukB null mutants have common phenotypes such as temperature-dependent colony formation, anucleate cell production, chromosome cutting by septum closure, and abnormal localization of SeqA-DNA clusters [3].

Biological context of mukE

• When kicA disruptant cells bearing a temperature-sensitive replication plasmid carrying the kicA+ gene were grown at 30 degrees C and then transferred to 42 degrees C, the mutant cells gradually lost colony-forming ability, even in the presence of a mukB+ plasmid [4].

Regulatory relationships of mukE

• Rates of protein synthesis, but not of RNA or DNA synthesis, fell dramatically during incubation at 42 degrees C. These results suggested that the kicB gene encodes a killing factor and the kicA gene codes for a protein that suppresses the killing function of the kicB gene product [4].

Other interactions of mukE

• Here, we report that mukF and mukE null mutants are both temperature-sensitive for colony formation and produce anucleate cells even at the permissive temperature [1].
• In null mutants for the mukF, mukE, and mukB genes, the synchronous initiation of chromosome replication was not affected [1].

References