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Gene Review:

cbdA - cytochrome bd-II oxidase, subunit I

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0969, JW0960, appC, cyxA

Atlung, T. et al., Domka, J. et al., Sturr, M.G. et al., Dassa, J. et al.

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Disease relevance of appC

An internal peptide from subunit I was sequenced, and it yielded the same primary sequence as is found in positions 496 to 510 of E. coli appC [1].

High impact information on appC

Cold-shock protein transcriptional regulators (cspABFGI) appear to be positive biofilm regulators, and deletions in respiratory genes (e.g. hyaACD, hyfCG, appC, narG) increased biofilm formation sevenfold [2].
The analysis showed that the cyxAB and the appA genes are cotranscribed from a potentially strong promoter, Pcyx, located immediately upstream of cyxA and that the operon in addition contains an internal promoter, PappA, contributing significantly to the transcription of the appA gene [3].
Genes appC and appB encode proteins of Mr 58,133 and 42,377, respectively, which have the characteristics of integral membrane proteins [4].

References

Purification of a cytochrome bd terminal oxidase encoded by the Escherichia coli app locus from a delta cyo delta cyd strain complemented by genes from Bacillus firmus OF4. Sturr, M.G., Krulwich, T.A., Hicks, D.B. J. Bacteriol. (1996) [Pubmed]
Temporal gene-expression in Escherichia coli K-12 biofilms. Domka, J., Lee, J., Bansal, T., Wood, T.K. Environ. Microbiol. (2007) [Pubmed]
Role of the transcriptional activator AppY in regulation of the cyx appA operon of Escherichia coli by anaerobiosis, phosphate starvation, and growth phase. Atlung, T., Brøndsted, L. J. Bacteriol. (1994) [Pubmed]
A new oxygen-regulated operon in Escherichia coli comprises the genes for a putative third cytochrome oxidase and for pH 2.5 acid phosphatase (appA). Dassa, J., Fsihi, H., Marck, C., Dion, M., Kieffer-Bontemps, M., Boquet, P.L. Mol. Gen. Genet. (1991) [Pubmed]

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