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Gene Review

mfd  -  transcription-repair coupling factor

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1100, JW1100
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Disease relevance of mfd

  • It has been shown previously that in Escherichia coli the mfd (mutation frequency decline) gene is necessary for strand-specific repair [1].

High impact information on mfd


Biological context of mfd


Associations of mfd with chemical compounds

  • Unexpectedly, however, (1) an mfd mutation reduced repair in the downstream domain even when transcription was at a very low level and (2) induction of lacZ transcription with isopropyl-beta-D-thiogalactoside overcame this reduction [3].


  1. Molecular mechanism of transcription-repair coupling. Selby, C.P., Sancar, A. Science (1993) [Pubmed]
  2. DNA excision repair. Sancar, A. Annu. Rev. Biochem. (1996) [Pubmed]
  3. Intragenic domains of strand-specific repair in Escherichia coli. Kunala, S., Brash, D.E. J. Mol. Biol. (1995) [Pubmed]
  4. Structural basis for transcription-coupled repair: the N terminus of Mfd resembles UvrB with degenerate ATPase motifs. Assenmacher, N., Wenig, K., Lammens, A., Hopfner, K.P. J. Mol. Biol. (2006) [Pubmed]
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