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Gene Review

clpA  -  ATPase and specificity subunit of ClpA...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0873, JW0866, lopD
 
 
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Disease relevance of clpA

  • The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate [1].
  • Antibodies against purified ClpA were used to identify lambda transducing phage bearing the clpA gene [2].
 

High impact information on clpA

 

Associations of clpA with chemical compounds

  • The degradation of abnormal canavanine-containing proteins is defective in clpA mutants especially in cells that also have a lon- mutation [2].

References

  1. The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate. Gottesman, S., Clark, W.P., Maurizi, M.R. J. Biol. Chem. (1990) [Pubmed]
  2. The two-component, ATP-dependent Clp protease of Escherichia coli. Purification, cloning, and mutational analysis of the ATP-binding component. Katayama, Y., Gottesman, S., Pumphrey, J., Rudikoff, S., Clark, W.P., Maurizi, M.R. J. Biol. Chem. (1988) [Pubmed]
  3. Family of the major cold-shock protein, CspA (CS7.4), of Escherichia coli, whose members show a high sequence similarity with the eukaryotic Y-box binding proteins. Lee, S.J., Xie, A., Jiang, W., Etchegaray, J.P., Jones, P.G., Inouye, M. Mol. Microbiol. (1994) [Pubmed]
  4. Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responses. Ekaza, E., Teyssier, J., Ouahrani-Bettache, S., Liautard, J.P., Köhler, S. J. Bacteriol. (2001) [Pubmed]
 
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