The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

murC  -  UDP-N-acetylmuramate:L-alanine ligase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0092, JW0089
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of murC


High impact information on murC

  • Viability of the E. coliDeltaddlADeltaddlB mutant in the absence of exogenous D-Ala-D-Ala dipeptide became dependent on the expression of the chlamydial murC-ddl thus demonstrating functional ligase activity [3].
  • The N-terminal sequence of the purified protein correlated with the nucleotide sequence of the murC gene [1].
  • Plasmid pAM1005, in which the promoter and ribosome-binding site region of murC were removed and in which the gene was directly under the control of promoter trc, led to a 2000-fold amplification of the L-alanine-adding activity after induction by isopropyl-thio-beta-D-galactopyranoside [1].
  • These results suggest that P. gingivalis contains a homologue of the E. coli peptidoglycan synthesis gene murC and indicate the possibility of a cluster of genes responsible for cell division and cell growth, as in the E. coli mra region [2].


  1. Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramate:L-alanine ligase from Escherichia coli. Liger, D., Masson, A., Blanot, D., van Heijenoort, J., Parquet, C. Eur. J. Biochem. (1995) [Pubmed]
  2. A murC gene in Porphyromonas gingivalis 381. Ansai, T., Yamashita, Y., Awano, S., Shibata, Y., Wachi, M., Nagai, K., Takehara, T. Microbiology (Reading, Engl.) (1995) [Pubmed]
  3. Characterization of Chlamydia MurC-Ddl, a fusion protein exhibiting D-alanyl-D-alanine ligase activity involved in peptidoglycan synthesis and D-cycloserine sensitivity. McCoy, A.J., Maurelli, A.T. Mol. Microbiol. (2005) [Pubmed]
WikiGenes - Universities