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Disease relevance of Porphyromonas


High impact information on Porphyromonas


Chemical compound and disease context of Porphyromonas


Biological context of Porphyromonas


Anatomical context of Porphyromonas


Gene context of Porphyromonas


Analytical, diagnostic and therapeutic context of Porphyromonas


  1. Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway. Imamura, T., Pike, R.N., Potempa, J., Travis, J. J. Clin. Invest. (1994) [Pubmed]
  2. Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold. Eichinger, A., Beisel, H.G., Jacob, U., Huber, R., Medrano, F.J., Banbula, A., Potempa, J., Travis, J., Bode, W. EMBO J. (1999) [Pubmed]
  3. Differential induction of endotoxin tolerance by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli. Martin, M., Katz, J., Vogel, S.N., Michalek, S.M. J. Immunol. (2001) [Pubmed]
  4. Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis. Wingrove, J.A., DiScipio, R.G., Chen, Z., Potempa, J., Travis, J., Hugli, T.E. J. Biol. Chem. (1992) [Pubmed]
  5. Cloning, characterization, and antigen specificity of T-lymphocyte subsets extracted from gingival tissue of chronic adult periodontitis patients. Wassenaar, A., Reinhardus, C., Thepen, T., Abraham-Inpijn, L., Kievits, F. Infect. Immun. (1995) [Pubmed]
  6. A novel superfamily of enzymes that catalyze the modification of guanidino groups. Shirai, H., Blundell, T.L., Mizuguchi, K. Trends Biochem. Sci. (2001) [Pubmed]
  7. Protease-activated receptor-2 activation: a major role in the pathogenesis of porphyromonas gingivalis infection. Holzhausen, M., Spolidorio, L.C., Ellen, R.P., Jobin, M.C., Steinhoff, M., Andrade-Gordon, P., Vergnolle, N. Am. J. Pathol. (2006) [Pubmed]
  8. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Al-Mashat, H.A., Kandru, S., Liu, R., Behl, Y., Desta, T., Graves, D.T. Diabetes (2006) [Pubmed]
  9. A novel Porphyromonas gingivalis FeoB plays a role in manganese accumulation. Dashper, S.G., Butler, C.A., Lissel, J.P., Paolini, R.A., Hoffmann, B., Veith, P.D., O'Brien-Simpson, N.M., Snelgrove, S.L., Tsiros, J.T., Reynolds, E.C. J. Biol. Chem. (2005) [Pubmed]
  10. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. Martin, M., Schifferle, R.E., Cuesta, N., Vogel, S.N., Katz, J., Michalek, S.M. J. Immunol. (2003) [Pubmed]
  11. The lipid A moiety of Porphyromonas gingivalis lipopolysaccharide specifically mediates the activation of C3H/HeJ mice. Tanamoto, K., Azumi, S., Haishima, Y., Kumada, H., Umemoto, T. J. Immunol. (1997) [Pubmed]
  12. Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins. Pike, R., McGraw, W., Potempa, J., Travis, J. J. Biol. Chem. (1994) [Pubmed]
  13. Inhibition of C3 and IgG proteolysis enhances phagocytosis of Porphyromonas gingivalis. Cutler, C.W., Arnold, R.R., Schenkein, H.A. J. Immunol. (1993) [Pubmed]
  14. Activation of the proton transfer pathway in catalysis by iron superoxide dismutase. Greenleaf, W.B., Silverman, D.N. J. Biol. Chem. (2002) [Pubmed]
  15. Structural analysis of a novel anionic polysaccharide from Porphyromonas gingivalis strain W50 related to Arg-gingipain glycans. Paramonov, N., Rangarajan, M., Hashim, A., Gallagher, A., Aduse-Opoku, J., Slaney, J.M., Hounsell, E., Curtis, M.A. Mol. Microbiol. (2005) [Pubmed]
  16. The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities. Sztukowska, M., Sroka, A., Bugno, M., Banbula, A., Takahashi, Y., Pike, R.N., Genco, C.A., Travis, J., Potempa, J. Mol. Microbiol. (2004) [Pubmed]
  17. Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes. Ally, N., Whisstock, J.C., Sieprawska-Lupa, M., Potempa, J., Le Bonniec, B.F., Travis, J., Pike, R.N. Biochemistry (2003) [Pubmed]
  18. Proteins with molecular masses of 50 and 80 kilodaltons encoded by genes downstream from the fimbrilin gene (fimA) are components associated with fimbriae in the oral anaerobe Porphyromonas gingivalis. Yoshimura, F., Takahashi, Y., Hibi, E., Takasawa, T., Kato, H., Dickinson, D.P. Infect. Immun. (1993) [Pubmed]
  19. In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis. Isogai, E., Isogal, H., Kimura, K., Fujii, N., Takagi, S., Hirose, K., Hayashi, M. Infect. Immun. (1996) [Pubmed]
  20. Downregulation of the DNA-binding activity of nuclear factor-kappaB p65 subunit in Porphyromonas gingivalis fimbria-induced tolerance. Hajishengallis, G., Genco, R.J. Infect. Immun. (2004) [Pubmed]
  21. Proteolysis of human monocyte CD14 by cysteine proteinases (gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsiveness. Sugawara, S., Nemoto, E., Tada, H., Miyake, K., Imamura, T., Takada, H. J. Immunol. (2000) [Pubmed]
  22. CD14 employs hydrophilic regions to "capture" lipopolysaccharides. Cunningham, M.D., Shapiro, R.A., Seachord, C., Ratcliffe, K., Cassiano, L., Darveau, R.P. J. Immunol. (2000) [Pubmed]
  23. Targeted disruption of fibronectin-integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50. Scragg, M.A., Cannon, S.J., Rangarajan, M., Williams, D.M., Curtis, M.A. Infect. Immun. (1999) [Pubmed]
  24. Resistance of a Tn4351-generated polysaccharide mutant of Porphyromonas gingivalis to polymorphonuclear leukocyte killing. Genco, C.A., Schifferle, R.E., Njoroge, T., Forng, R.Y., Cutler, C.W. Infect. Immun. (1995) [Pubmed]
  25. Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Lourbakos, A., Potempa, J., Travis, J., D'Andrea, M.R., Andrade-Gordon, P., Santulli, R., Mackie, E.J., Pike, R.N. Infect. Immun. (2001) [Pubmed]
  26. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. Pulendran, B., Kumar, P., Cutler, C.W., Mohamadzadeh, M., Van Dyke, T., Banchereau, J. J. Immunol. (2001) [Pubmed]
  27. Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells. Nassar, H., Chou, H.H., Khlgatian, M., Gibson, F.C., Van Dyke, T.E., Genco, C.A. Infect. Immun. (2002) [Pubmed]
  28. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Darveau, R.P., Pham, T.T., Lemley, K., Reife, R.A., Bainbridge, B.W., Coats, S.R., Howald, W.N., Way, S.S., Hajjar, A.M. Infect. Immun. (2004) [Pubmed]
  29. Association of mitogen-activated protein kinase pathways with gingival epithelial cell responses to Porphyromonas gingivalis infection. Watanabe, K., Yilmaz, O., Nakhjiri, S.F., Belton, C.M., Lamont, R.J. Infect. Immun. (2001) [Pubmed]
  30. Mice lacking monocyte chemoattractant protein 1 have enhanced susceptibility to an interstitial polymicrobial infection due to impaired monocyte recruitment. Chae, P., Im, M., Gibson, F., Jiang, Y., Graves, D.T. Infect. Immun. (2002) [Pubmed]
  31. Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases. Pavloff, N., Pemberton, P.A., Potempa, J., Chen, W.C., Pike, R.N., Prochazka, V., Kiefer, M.C., Travis, J., Barr, P.J. J. Biol. Chem. (1997) [Pubmed]
  32. Purification and characterization of a collagen-degrading protease from Porphyromonas gingivalis. Bedi, G.S., Williams, T. J. Biol. Chem. (1994) [Pubmed]
  33. Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis. Masuda, K., Yoshioka, M., Hinode, D., Nakamura, R. Infect. Immun. (2002) [Pubmed]
  34. Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis. Tang, K.H., Harms, A., Frey, P.A. Biochemistry (2002) [Pubmed]
  35. Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster. Collins, J.G., Smith, M.A., Arnold, R.R., Offenbacher, S. Infect. Immun. (1994) [Pubmed]
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