The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

sapD  -  antimicrobial peptide ABC transporter ATPase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1286, JW1284, trkE
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of sapD

  • In addition, a plasmid containing V. alginolyticus trkAH permitted growth of an E. coli delta sapABCDF (delta trkE) strain at low K+ concentrations [1].

High impact information on sapD

  • The activity of the two almost identical K+-uptake systems, Trk(H) and Trk(G), from Escherichia coli K-12 depends completely and partially on the presence of the trkE gene, respectively. trkE maps inside the sapABCDF operon, which encodes an ATP-binding cassette (ABC) transporter of unknown function from the subgroup of peptide-uptake systems [2].
  • Nucleotide sequence and functional analyses confirm that the specific regulatory-region-like sequence R&R* that resides inside the sapD gene and before the sapF gene functions in gene expression and regulation; also, it is regulated by the LuxR-AI complex of the V. fischeri lux regulon [3].

Biological context of sapD

  • Measurements of net K(+)-uptake rates indicated that the presence of these genes in E. coli renders the Trk systems independent of products from the E. coli sapABCDF (trkE) operon [1].


  1. Cloning of the trkAH gene cluster and characterization of the Trk K(+)-uptake system of Vibrio alginolyticus. Nakamura, T., Yamamuro, N., Stumpe, S., Unemoto, T., Bakker, E.P. Microbiology (Reading, Engl.) (1998) [Pubmed]
  2. Identification of the ABC protein SapD as the subunit that confers ATP dependence to the K+-uptake systems Trk(H) and Trk(G) from Escherichia coli K-12. Harms, C., Domoto, Y., Celik, C., Rahe, E., Stumpe, S., Schmid, R., Nakamura, T., Bakker, E.P. Microbiology (Reading, Engl.) (2001) [Pubmed]
  3. Identification and analysis of the sap genes from Vibrio fischeri belonging to the ATP-binding cassette gene family required for peptide transport and resistance to antimicrobial peptides. Chen, H.Y., Weng, S.F., Lin, J.W. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
WikiGenes - Universities