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Gene Review: 

sapD  -  antimicrobial peptide ABC transporter ATPase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1286, JW1284, trkE
 
 
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Disease relevance of sapD

  • In addition, a plasmid containing V. alginolyticus trkAH permitted growth of an E. coli delta sapABCDF (delta trkE) strain at low K+ concentrations [1].
 

High impact information on sapD

  • The activity of the two almost identical K+-uptake systems, Trk(H) and Trk(G), from Escherichia coli K-12 depends completely and partially on the presence of the trkE gene, respectively. trkE maps inside the sapABCDF operon, which encodes an ATP-binding cassette (ABC) transporter of unknown function from the subgroup of peptide-uptake systems [2].
  • Nucleotide sequence and functional analyses confirm that the specific regulatory-region-like sequence R&R* that resides inside the sapD gene and before the sapF gene functions in gene expression and regulation; also, it is regulated by the LuxR-AI complex of the V. fischeri lux regulon [3].
 

Biological context of sapD

  • Measurements of net K(+)-uptake rates indicated that the presence of these genes in E. coli renders the Trk systems independent of products from the E. coli sapABCDF (trkE) operon [1].

References

  1. Cloning of the trkAH gene cluster and characterization of the Trk K(+)-uptake system of Vibrio alginolyticus. Nakamura, T., Yamamuro, N., Stumpe, S., Unemoto, T., Bakker, E.P. Microbiology (Reading, Engl.) (1998) [Pubmed]
  2. Identification of the ABC protein SapD as the subunit that confers ATP dependence to the K+-uptake systems Trk(H) and Trk(G) from Escherichia coli K-12. Harms, C., Domoto, Y., Celik, C., Rahe, E., Stumpe, S., Schmid, R., Nakamura, T., Bakker, E.P. Microbiology (Reading, Engl.) (2001) [Pubmed]
  3. Identification and analysis of the sap genes from Vibrio fischeri belonging to the ATP-binding cassette gene family required for peptide transport and resistance to antimicrobial peptides. Chen, H.Y., Weng, S.F., Lin, J.W. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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