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Gene Review:

uvrY - response regulator in two-component...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1913, JW1899, gacA, sirA, yecB

Herren, C.D. et al., Pernestig, A.K. et al., Suzuki, K. et al., Mondrag??n, V. et al.

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Disease relevance of uvrY

The barA and uvrY genes of Escherichia coli encode a two-component sensor kinase and a response regulator, respectively [1].

High impact information on uvrY

A number of virulence determinants, such as the abilities to adhere, invade, persist within tissues, survive within macrophages, and resist bactericidal effects of serum complement, were compromised in mutants lacking either the barA or uvrY gene [2].
Both csrA and uvrY were required for optimal barA expression [3].

Biological context of uvrY

Here we show that mutations in the sensor kinase gene, barA, or the response regulator gene, uvrY, in uropathogenic E. coli drastically affect survival in long-term competition cultures [4].

Other interactions of uvrY

The uvrY defect was severalfold more severe than that of barA [3].

References

pH-Dependent Activation of the BarA-UvrY Two-Component System in Escherichia coli. Mondrag??n, V., Franco, B., Jonas, K., Suzuki, K., Romeo, T., Melefors, O., Georgellis, D. J. Bacteriol. (2006) [Pubmed]
The BarA-UvrY two-component system regulates virulence in avian pathogenic Escherichia coli O78:K80:H9. Herren, C.D., Mitra, A., Palaniyandi, S.K., Coleman, A., Elankumaran, S., Mukhopadhyay, S. Infect. Immun. (2006) [Pubmed]
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli. Suzuki, K., Wang, X., Weilbacher, T., Pernestig, A.K., Melefors, O., Georgellis, D., Babitzke, P., Romeo, T. J. Bacteriol. (2002) [Pubmed]
The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources. Pernestig, A.K., Georgellis, D., Romeo, T., Suzuki, K., Tomenius, H., Normark, S., Melefors, O. J. Bacteriol. (2003) [Pubmed]

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