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Gene Review

rcsA  -  transcriptional regulator of colanic acid...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1949, JW1935, cpsR
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Disease relevance of rcsA

  • A small RNA acts as an antisilencer of the H-NS-silenced rcsA gene of Escherichia coli [1].
  • The DNA and protein sequences are highly homologous to the rcsA gene and protein from Klebsiella pneumoniae and other species [2].

High impact information on rcsA

  • One is rcsA, which specifies a positive transcriptional regulator of the cps genes, which are involved in capsular polysaccharide synthesis [3].
  • It was established that in the presence of multicopy rcsA or with disruption of lon, CP9 can be induced to produce a group 1 capsule [4].
  • We have cloned rcsA from E. coli O9:K30 and determined the nucleotide sequence [5].
  • DNA sequence analysis of the rcsA gene reveals a single open reading frame for a 23,500-Da highly basic protein (pI = 9.9), consistent with the observed size of the purified subunit of RcsA [2].
  • These activities were augmented when crcB was overexpressed with cspE (100-fold camphor resistance and 2.1-fold induction of rcsA) [6].

Chemical compound and disease context of rcsA

  • These K-12/K30 hybrid strains did not produce colanic acid, suggesting that the genes for synthesis of colanic acid and the K30 capsular polysaccharide may be allelic. rcsA sequences were also detected in the group II strains E. coli K1 and K5 [5].

Biological context of rcsA


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