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Gene Review

cspE  -  constitutive cold shock family...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0616, JW0618, gicA, msmC
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Disease relevance of cspE


High impact information on cspE

  • Characterization of Escherichia coli cspE, whose product negatively regulates transcription of cspA, the gene for the major cold shock protein [2].
  • CspE is highly produced at 37 degrees C. The synthesis level of CspE transiently increased during the growth lag period after dilution of stationary-phase cells into the fresh medium at 37 degrees C. This is consistent with the delta cspE phenotype of the longer growth lag period after dilution [2].
  • DNA sequencing revealed that the msmB gene was identical to the cspC gene and that the msmC gene had not been described before [3].
  • Deletion of crcA, cspE and crcB exacerbates the nucleoid morphology defects of the topo IV Ts mutants [4].
  • These activities were augmented when crcB was overexpressed with cspE (100-fold camphor resistance and 2.1-fold induction of rcsA) [4].

Chemical compound and disease context of cspE


Biological context of cspE

  • In this study, we analyzed global transcript profiles of cells lacking cspE and cspC as well as cells individually overexpressing these proteins or a CspE mutant that is unable to melt nucleic acids and is defective in cold acclimation [6].

Other interactions of cspE

  • In the delta cspE strain, the synthesis of a number of proteins at 37 degrees C was found to be altered and cspA was derepressed [2].

Analytical, diagnostic and therapeutic context of cspE


  1. Loss of Expression of cspC, a Cold Shock Family Gene, Confers a Gain of Fitness in Escherichia coli K-12 Strains. Rath, D., Jawali, N. J. Bacteriol. (2006) [Pubmed]
  2. Characterization of Escherichia coli cspE, whose product negatively regulates transcription of cspA, the gene for the major cold shock protein. Bae, W., Phadtare, S., Severinov, K., Inouye, M. Mol. Microbiol. (1999) [Pubmed]
  3. Cloning, sequencing, and characterization of multicopy suppressors of a mukB mutation in Escherichia coli. Yamanaka, K., Mitani, T., Ogura, T., Niki, H., Hiraga, S. Mol. Microbiol. (1994) [Pubmed]
  4. Phenotypic characterization of overexpression or deletion of the Escherichia coli crcA, cspE and crcB genes. Sand, O., Gingras, M., Beck, N., Hall, C., Trun, N. Microbiology (Reading, Engl.) (2003) [Pubmed]
  5. A common regulator of cold and radiation response in Escherichia coli. Mangoli, S., Sanzgiri, V.R., Mahajan, S.K. J. Environ. Pathol. Toxicol. Oncol. (2001) [Pubmed]
  6. Analysis of Escherichia coli global gene expression profiles in response to overexpression and deletion of CspC and CspE. Phadtare, S., Tadigotla, V., Shin, W.H., Sengupta, A., Severinov, K. J. Bacteriol. (2006) [Pubmed]
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