Disease relevance of nlpE

• Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli [1].
• Three distinct clones from a Salmonella typhimurium genomic library were identified which suppressed the copper-sensitive (Cu(s)) phenotype of cutF mutants of Escherichia coli [2].

High impact information on nlpE

• However, inactivation of the nlpE gene or mutations eliminating the ability to make acetyl phosphate did not alter the high level of degP expression in pss-93 mutants [3].
• Elevated levels of acetyl phosphate and nlpE gene product can result in activation of the Cpx pathway [3].
• Accordingly, the gene has been named nlpE (for new lipoprotein E) [4].

Biological context of nlpE

• Copper-sensitive cutC and cutF mutants were transformed with a genomic library of E. coli, and copper-tolerant transformants were selected [1].

References