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Gene Review:

bcp - peroxiredoxin; thiol peroxidase,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2476, JW2465

Wang, G. et al., Choi, J. et al., Ghrist, A.C. et al.

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Disease relevance of bcp

Escherichia coli p20 is a thioredoxin-dependent thiol peroxidase [1].

High impact information on bcp

The bcp mutant strain could colonize mouse stomachs, although colonization by the wild-type strain was slightly better than that by the mutant strain at 1 week after host inoculation [2].
Introduction of an intact bcp gene at an unrelated locus in the bcp strain restored the wild-type-like oxidative stress resistance phenotype [2].
The overlapping functions and activities of BCP and AhpC probably explain why the bcp mutant displayed a relatively weak oxidative stress resistance phenotype [2].
These results show that gcvR and bcp do not form an operon [3].

References

Crystallization and preliminary X-ray analysis of Escherichia coli p20, a novel thiol peroxidase. Choi, J., Choi, S., Choi, J., Cha, M.K., Kim, I.H., Shin, W. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
Contribution of the Helicobacter pylori thiol peroxidase bacterioferritin comigratory protein to oxidative stress resistance and host colonization. Wang, G., Olczak, A.A., Walton, J.P., Maier, R.J. Infect. Immun. (2005) [Pubmed]
Promoter characterization and constitutive expression of the Escherichia coli gcvR gene. Ghrist, A.C., Stauffer, G.V. J. Bacteriol. (1998) [Pubmed]

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